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Ecotoxicological information

Short-term toxicity to aquatic invertebrates

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Link to relevant study record(s)

Description of key information

In the key study, the acute toxicity to Daphnia magna of tetradonium bromide was determined to be 22 µg/L  representing EC50 (48h).  The EC50(48h) of 22 µg/L was selected for the safety assessment. The key study is supported by two other studies performed on Daphnia magna. EC50(24h) values reported are 91 to 140 µg/L.

Key value for chemical safety assessment

EC50/LC50 for freshwater invertebrates:
22 µg/L

Additional information

Short-term toxicity data were obtained from three different studies all performed on Daphnia magna. In the key study, the acute toxicity to Daphnia magna of tetradonium bromide was determined to be 22 µg/L representing the EC50 (48h). Other studies supported the findings in the key study with EC50(24h) reported based on nominal concentrations as 91 to 140 µg/L. The EC50(48h) of 22 µg/L is selected for the safety assessment, as it is the best described study, with no deviation from the OECD guideline. No data have been obtained for marine invertebrates.

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