Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 700-066-7 | CAS number: 1472633-72-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
Algal inhibition study conducted on boric acid, the hydrolysis product of the reference substance, which is applicable to use in the evaluation of the reference substances ecotoxicological properties. The 3 day EC50 (growth rate) was 52.5 mg B/L.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 52.5 mg/L
- EC10 or NOEC for freshwater algae:
- 17.5 mg/L
Additional information
The reference substance (BAGE) hydrolyses within less than an hour to its hydrolysis products: Boric acid and glycerol. Therefore, conducting an algal inhibition study on the reference substance itself was considered not to be feasible. If a study was conducted on the reference substance, it would give a result representative of the hydrolysis products mentioned above.
An assessment of boric acid has therefore been made based on available algal study data.
Boric acid
Hanstveit and Oldersma (2000):
An algal inhibition study was conducted on Boric acid according to OECD Guideline 201/EU Method C.3.
Selenastrum capricornutum was exposed for 74.5 hours to the following concentrations of test substance.
0, 32, 56, 100, 181, 321, 562 mg/L boric acid, equivalent to 0, 5.6, 9.8, 17.5, 31.7, 56.2, 98.4 mg B/L.
Measured concentrations were found to be 95.4 -94.7% of the nominal concentrations.
The following results were obtained (concentration based on boron element):
3 day NOEC (growth rate): 17.5 mg/L
3 day EC50 (growth rate): 52.5 mg/L
3 day EC50 (biomass): 40 mg/L
Glycerol
Glycerol is the other hydrolysis product of the reference substance, BAGE. It is not classified for the environment according to CLP or DSD.
Available data (see section 13) suggests that glycerol is of low toxicity to algae.
Refer to section 13, Ecotoxicological expert report (BAGE: Evaluation of Environmental Fate and Ecotoxicity Properties) for further details of the evalaution of ecotoxicological properties of the reference substance and its hydrolysis products, especially for additional information on glycerol.
Supporting data
As the reference substance hydrolyses within less than an hour to its hydrolysis products; Boric acid and glycerol it was not feasible to conduct an algal inhibition study on the reference substance, as the result will be representative of the hydrolysis products Boric acid and glycerol.
A QSAR prediction has therefore been made for the reference substance (BAGE), using EPIWIN program ECOSAR (v0.99h).
The predicted 96 hour EC50 of green algae was predicted to be 4.07 x 1010mg/l. This value is greater than the predicted water solubility of the reference substance.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
