Registration Dossier
Registration Dossier
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EC number: 923-835-0 | CAS number: -
Bioaccumulation: aquatic / sediment
Administrative data
- Endpoint:
- bioaccumulation: aquatic / sediment
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
Data source
Materials and methods
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- Considering REACH Annex IX 9.3.2 criteria, bioaccumulation in aquatic species, preferably fish, may be proposed. However, as the substance is poorly soluble in water, exposure of the aquatic compartment is unlikely: this test is not proposed to be performed.
- Executive summary:
No experimental data on aquatic bioaccumulation are available for the substance.
The study for determine the partition coefficient (log KOW) give a data range from 4.3 to 9.7 indicating high bioaccumulation potential.
The substance contains about 50 – 60 % of 1-eicosanol (log KOW= 8.7) and 1-docosanol (log KOW = 9.7). The alkyl chain length has the most impact on the log KOW value.
A quantitative estimation of the bioconcentration factor (BCF) for fish can be performed according to the parabolic equation given in the Guidance on information requirements and chemical safety assessment (Chapter R.7c) for substances having a log Pow > 6 (with log KOW = 9.7) :
Parabolic equation:
log BCFfish = -0.20 x (log KOW)² + 2.74 x log KOW – 4.72
log BCFfish = -0.20 x (9.7)² + 2.74 x 9.7 – 4.72
log BCFfish = 3.04
BCFfish = 1096 L/kg
A BCF of 3.162 L/kg was estimated by BCFWIN using log KOW of 9.7. However, this method delivers many underestimations of BCFs. Hence, this QSAR-method is not reliable for estimating the bioaccumulation potential of the substance.
BCFWIN and equation lead to very different results.
Considering REACH Annex IX 9.3.2criteria, bioaccumulation in aquatic species, preferably fish, may be proposed. However, as the substance is poorly soluble in water, exposure of the aquatic compartment is unlikely: this test is not proposed to be performed.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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