Registration Dossier
Registration Dossier
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EC number: 279-900-2 | CAS number: 82104-74-3
Biodegradation in water and sediment: simulation tests
Administrative data
- Endpoint:
- biodegradation in water and sediment: simulation tests
- Type of information:
- calculation (if not (Q)SAR)
- Remarks:
- Migrated phrase: estimated by calculation
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- other: Prediction model
- Title:
- Biodegradation in water and sediment by Environmental Science Center’s PBT profiler
- Author:
- Environmental Science Center
- Year:
- 2 010
- Bibliographic source:
- PBT profiler, Office of Chemical Safety and Pollution Prevention , U.S. Environmental Protection Agency; version 1.301
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Modelling database
- Principles of method if other than guideline:
- PBT profiler database
- GLP compliance:
- no
Test material
- Reference substance name:
- 1,3-dihydro-1-oxoisobenzofuran-5-carbonitrile
- EC Number:
- 279-900-2
- EC Name:
- 1,3-dihydro-1-oxoisobenzofuran-5-carbonitrile
- Cas Number:
- 82104-74-3
- Molecular formula:
- C9H5NO2
- IUPAC Name:
- 1,3-dihydro-1-oxoisobenzofuran-5-carbonitrile
- Test material form:
- solid: crystalline
- Details on test material:
- - Name of test material: 1,3-dihydro-1-oxoisobenzofuran-5-carbonitrile
- Molecular formula: C9H5NO2
- Substance type: Organic
- Physical state: Solid
Constituent 1
- Radiolabelling:
- not specified
Study design
- Oxygen conditions:
- other: estimated database
- Inoculum or test system:
- not specified
- Parameter followed for biodegradation estimation:
- test mat. analysis
Reference substance
- Reference substance:
- not specified
Results and discussion
Mean total recoveryopen allclose all
- Compartment:
- other: water, material (mass) balance
- % Recovery:
- 24
- Compartment:
- other: sediment, material (mass) balance
- % Recovery:
- 0
% Degradationopen allclose all
- % Degr.:
- 50
- Parameter:
- other: half life
- Sampling time:
- 15 d
- Remarks on result:
- other: 15 days= 360hrs
- % Degr.:
- 50
- Parameter:
- other: half life
- Sampling time:
- 140 d
- Remarks on result:
- other: 140 days = 3360 hrs
Half-life of parent compound / 50% disappearance time (DT50)open allclose all
- Compartment:
- water
- DT50:
- 15 d
- Type:
- other: Estimated
- Remarks on result:
- other: other details not available
- Compartment:
- sediment
- DT50:
- 140 d
- Type:
- other: Estimated
- Remarks on result:
- other: other details not available
- Transformation products:
- not specified
- Evaporation of parent compound:
- not specified
- Volatile metabolites:
- not specified
- Residues:
- not specified
Any other information on results incl. tables
Media |
Half life (days) |
Percent in medium |
Water |
15 days |
24% |
Sediment |
140 days |
0% |
Applicant's summary and conclusion
- Conclusions:
- Half life value of 1,3-dihydro-1-oxoisobenzofuran-5-carbonitrile in water was estimated to be 15 days (360 hrs) while in sediment it is 140 days (3360 hrs) .Based on these half life values it is concluded that 1,3-dihydro-1-oxoisobenzofuran-5-carbonitrile is readily biodegradable(not persistent) in water where as it is non biodegradable(Persistent) in sediment.
- Executive summary:
By using level III fugacity model, half life value of 1,3-dihydro-1-oxoisobenzofuran-5-carbonitrile in water was estimated to be 15 days (360 hrs) while in sediment it is 140 days (3360 hrs) .Based on these half life values it is concluded that 1,3-dihydro-1-oxoisobenzofuran-5-carbonitrile is readily biodegradable(not persistent) in water where as it is non biodegradable(Persistent) in sediment.
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