Registration Dossier
Registration Dossier
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EC number: 309-643-4 | CAS number: 100656-54-0 The product obtained by acid leaching of copper speiss. Composed primarily of antimony, arsenic and lead with high precious metal content.
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation
- Remarks:
- other: calculation based on classification
- Type of information:
- calculation (if not (Q)SAR)
- Remarks:
- Migrated phrase: estimated by calculation
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: no GLP (but other Quality Assurance); software
Cross-reference
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- other: software
- Title:
- Unnamed
- Year:
- 2 010
Materials and methods
- Principles of method if other than guideline:
- The potential of the UVCB substance to be respiratory or skin sensitisation was established by classifying the complex metal substance according to rules for classification of mixtures for respiratory or skin sensitisation (EU CLP guidance section 3.4.3 pg 277ff). The classification criteria (as set out in EU CLP Guidance Annex I: 3.4.2.1 pg 269) can be used to estimate effects derived from that classification/hazard. In vitro solubility tests, mimicking sweat fluids in accordance to EN1811, were carried out. The results are used to refine/confirm the hazard classification.
- GLP compliance:
- no
- Remarks:
- (CLP calculation software)
- Type of study:
- other: calculation
Test material
- Reference substance name:
- Residues, copper speiss acid leaching
- EC Number:
- 309-643-4
- EC Name:
- Residues, copper speiss acid leaching
- Cas Number:
- 100656-54-0
- IUPAC Name:
- Residues, copper speiss acid leaching
- Details on test material:
- Typical across industry, as defined in IUCLID 1.2.
Constituent 1
Results and discussion
Any other information on results incl. tables
The calculated classification via mixture toxicity rules is dependent on elemental composition and information from minerology.
Applicant's summary and conclusion
- Interpretation of results:
- other: Results dependent on elemental composition
- Conclusions:
- Result can be used to predict skin sensitizing effect and to classify the UVCB substance. See Section 2 for potential resulting classifications.
- Executive summary:
The study provides a conservative estimate of the potential for skin sensitisation, derived on the basis of the Classification outcome (Mixture CLP rules).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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