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Diss Factsheets
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EC number: 209-708-6 | CAS number: 591-22-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Using an in vitro protocol, the substance is irritating but noncorrosive, but in an in vivo protocol, the substance was corrosive.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
There are conflicting test results for the irritation/corrosion of 3,5-dimethylpyridine. In an in vitro test, the OECD 435 barrier method (Corrositex) indicated that the substance was not corrosive but was irritating. In contrast, in an in vivo test where the substance was placed on the skin of rabbits for 4 hours under a semiocclusive bandage, the substance caused skin burns and was categorized as corrosive. In neither study was the purity of the substance provided nor compared with that of the current commercial product. No data were provided in the Corrositex study concerning the behaviour of the substance in the color detection system (CDS) associated with identification of corrosive chemicals; data was provided only for the CDS used for chemicals classified as "irritating". The in vivo study warrants a higher weight of evidence than the in vitro cell-free study. The substance is classified as corrosive.
Justification for selection of skin irritation / corrosion endpoint:
Experiment result in vivo
Effects on skin irritation/corrosion: corrosive
Justification for classification or non-classification
The substance causes corrosion within 4 h of application to the skin of rabbits. This qualifies as Category 1 under Regulation EC No. 1272/2008.
Based on the finding of corrosion in the skin irritation/corrosion study, an eye irritation study was not undertaken. The substance is classified as Category 1, causes serious eye damage, based on the recommendation by ECHA in Section 3.3 of Guidance on the Application of the CLP Criteria, Version 2, 27 April 2012, that eye damage is implicit for substances classified as skin corrosive category 1.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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