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EC number: 265-512-0 | CAS number: 65140-91-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The test substance was not irritating to the skin or to the eye. In human workers, isolated cases of respiratory irritation have been observed in the past.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
Skin irritation
In a Draize Test 3 male and 3 female rabbits were treated with a gauze patch, soaked with the test substance (0.5 g; Ciba-Geigy, 1974). The animals were treated on intact and scarified skin for 24 h under occlusive conditions. The skin was evaluated 24 h and 72 h after removal of the test substance, no scores were recorded for the 48 h time point. All scores for the intact skin were zero for edema and erythema in all animals at any recorded time point. A mild erythema was observed in 4/6 animals at the 24 hour time point when tested on scarified skin (average score = 0.67), reversible within 72 hours. Based on the data obtained for intact skin, average irritation scores for edema and erythema of 0.0 were calculated for all animals. Findings on scarified skin are not relevant for assessment of irritation potential based on current regulations, however even for scarified skin the observed skin reactions are far below the level of regulatory threshold. Since all scores for intact skin were zero, the missing 48 h time point is not considered to affect the assessment of the results negatively. Thus, based on this data, the test substance is considered to be not irritating to the skin.
Eye irritation
In a Draize Test, 0.1 g of the test substance was instilled into the conjunctival sac of the left eye of 3 male and 3 female animals with a spatula. After application, the eyelids were held open for a few seconds. The right eye served as a control. The treated eyes of three rabbits were each rinsed with 10 mL lukewarm water about 30 seconds after treatment. The reactions were appraised with a slit-lamp after 24 hours and after 2, 3, 4 and 7 days. No ocular reactions were observed after 24, 48, 72 h and after 4 and 7 days in both rinsed and un-rinsed eyes, all scores recorded were zero. Thus, the test substance is considered as not irritating to the eye.
Respiratory irritation
In animal studies, no indication for an irritation potential was evident for the test article. However, isolated cases of respiratory irritation have been observed in highly exposed workers. It is unknown to what concentrations of test substance these workers have been exposed. It is further unknown, whether these reactions were due to an irritating potential of the substance or due to extreme amounts of material being inhaled. Nevertheless, following the worst case principle, the substance is considered to be irritating to the respiratory system and requires classification with H335: may cause respiratory irritation.
Justification for selection of skin irritation / corrosion endpoint:
acceptable for assessment
Justification for selection of eye irritation endpoint:
acceptable for assessment
Effects on respiratory irritation: irritating
Justification for classification or non-classification
Dangerous Substance Directive (67/548/EEC)
- Based on the observations in human workers, the substance is classified with Xi; R37 Irritating to respiratory system.
Classification, Labeling, and Packaging Regulation (EC) No. 1272/2008:
- Based on the observations in human workers, the substance is classified with H335: May cause respiratory irritation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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