Registration Dossier

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
15 May 2013 to 17 March 2014
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Conducted according to current test guidelines and GLP compliant

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2014
Report date:
2014

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.8 (Partition Coefficient)
Deviations:
no
GLP compliance:
yes
Type of method:
HPLC method
Partition coefficient type:
octanol-water

Test material

Constituent 1
Chemical structure
Reference substance name:
Acetic acid 2-oxo-2H-pyridin-1-yl ester
EC Number:
689-986-7
Cas Number:
1742-79-6
Molecular formula:
C7H7NO3
IUPAC Name:
Acetic acid 2-oxo-2H-pyridin-1-yl ester
Constituent 2
Reference substance name:
1742-78-6
IUPAC Name:
1742-78-6
Test material form:
solid: particulate/powder
Remarks:
migrated information: powder
Details on test material:
Name: Oxypyrion acetate
CAS Number: 1742-78-6
Batch number: 14058400
Purity: 97.83%
Date of arrival: 22 April 2013
Expiry date: 30 November 2013
Storage conditions: Refrigerated (2 to 8°C)

Results and discussion

Partition coefficientopen allclose all
Type:
log Pow
Partition coefficient:
-1.56
Temp.:
25 °C
Remarks on result:
other: Peak 1 (0,32%)
Type:
log Pow
Partition coefficient:
-0.5
Temp.:
25 °C
Remarks on result:
other: Peak 2 (99,69%)
Details on results:
There were two chromatographic peaks attributable to Oxypyrion acetate, under the guideline test conditions.
The two Oxypyrion acetate peaks had retention times greater than that of dead time marker, formamide, but less than that of the lowest standard, 2-butanone.
As the retention time of the Oxypyrion acetate was outside the calibration range the Log Pow values are therefore extrapolated values.
Test 1: Peak 1: Log Pow = -1,62 (0,24 %); Peak 2: Log Pow = -0,49 (99,76 %)
Test 2: Peak 1: Log Pow = -1,50 (0,39 %); Peak 2: Log Pow = -0,50 (99,61 %)
Mean: Peak 1: Log Pow = -1,56 (0,32 %); Peak 2: Log Pow = -0,50 (99,69 %)

Applicant's summary and conclusion

Conclusions:
There were two chromatographic peaks attributable to Oxypyrion acetate, under the guideline test conditions.
The mean partition coefficient values (log Pow) determined were -1,56 (0,32 %) for Peak 1 and -0,50 (99,69 %) for Peak 2.