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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
16/05/1997 to 30/05/1997
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Guideline study with sufficient documentation

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1997
Report date:
1997

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
2-chloro-4,6-dimethoxy-1,3,5-triazine
EC Number:
221-541-0
EC Name:
2-chloro-4,6-dimethoxy-1,3,5-triazine
Cas Number:
3140-73-6
Molecular formula:
C5H6ClN3O2
IUPAC Name:
2-chloro-4,6-dimethoxy-1,3,5-triazine

Test animals

Species:
rabbit
Strain:
New Zealand White

Test system

Type of coverage:
occlusive
Preparation of test site:
clipped
Vehicle:
water
Controls:
not specified
Amount / concentration applied:
0.5 g + 0.5 ml Water
Duration of treatment / exposure:
4 h exposure
Observation period:
24h / 48h / 72h after removing of substance
Number of animals:
6

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
mean
Time point:
other: 1 h
Score:
ca. 2
Max. score:
2
Reversibility:
fully reversible
Irritation parameter:
edema score
Basis:
mean
Time point:
other: 1 h
Score:
ca. 3
Max. score:
4
Reversibility:
fully reversible
Irritation parameter:
erythema score
Basis:
mean
Time point:
other: 24 h
Score:
ca. 2
Max. score:
2
Reversibility:
fully reversible
Irritation parameter:
erythema score
Basis:
mean
Time point:
other: 48 h
Score:
ca. 2
Max. score:
2
Reversibility:
fully reversible
Irritation parameter:
erythema score
Basis:
mean
Time point:
other: 72 h
Score:
ca. 2
Max. score:
2
Reversibility:
fully reversible
Irritation parameter:
edema score
Basis:
mean
Time point:
other: 24 h
Score:
ca. 2.5
Max. score:
4
Reversibility:
fully reversible
Irritation parameter:
edema score
Basis:
mean
Time point:
other: 48 h
Score:
ca. 2
Max. score:
3
Reversibility:
fully reversible
Irritation parameter:
edema score
Basis:
mean
Time point:
other: 72 h
Score:
ca. 2
Max. score:
3
Reversibility:
fully reversible

Applicant's summary and conclusion

Interpretation of results:
moderately irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Accoring to the test result 2-Chloro-4,6-Dimethoxy-1,3,5-Triazine is moderate irritant to the skin.
Executive summary:

Accoring to the test result 2-Chloro-4,6-Dimethoxy-1,3,5-Triazine is moderate irritant to the skin.

6 from 6 rabbits had moderate skin irritation that where fully reversible.