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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1995-01-16 to 1995-02-15
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: no guideline followed but sufficientlydocumented

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1995
Report date:
1995

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Substance was applied to clipped skin of a rabbit
Mortality and clinical abnormalities were observed
GLP compliance:
no
Test type:
standard acute method

Test material

Constituent 1
Chemical structure
Reference substance name:
2-chloro-4,6-dimethoxy-1,3,5-triazine
EC Number:
221-541-0
EC Name:
2-chloro-4,6-dimethoxy-1,3,5-triazine
Cas Number:
3140-73-6
Molecular formula:
C5H6ClN3O2
IUPAC Name:
2-chloro-4,6-dimethoxy-1,3,5-triazine
Details on test material:
Material is called "018699" in this test. material is confirmed to be 2-Chloro-4,6-Dimethoxy-1,3,5-Triazine

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
not specified

Administration / exposure

Type of coverage:
occlusive
Vehicle:
water
Duration of exposure:
24h
Doses:
1000mg/kg bw
No. of animals per sex per dose:
3 animals per dose

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD0
Effect level:
> 1 000 mg/kg bw
Based on:
test mat.
Mortality:
none
Clinical signs:
other: Substance is considered corrosive to rabbit skin.

Any other information on results incl. tables

Study abnormalities

Animals affected

No observed / No Dosed

Day(s) of Occurrence

Mortality

0/3

-

Well-defined erythema

3/3

1-12

Very slight erythema

2/3

13-14

Blanching – mild

2/3

2-8

Blanching - moderate

2/3

5

Blanching – focal/pinpoint

2/3

3,4,8,9

Eschar – mild

2/3

4-14

Eschar - focal/pinpoint

2/3

2,3,10-14

Desquamation

3/3

6-14

Severe edema

3/3

1-4

Moderate edema

3/3

3-7

Slight edema

3/3

5-9

Very slight edema

3/3

9-14

Fecal stain

1/3

1,2

Few feces

3/3

3-5

Low food consumption

2/3

3,4

Dehydration

1/3

4-6

Ancillary irritation on the trunk outside the test site

1/3

1-7

Applicant's summary and conclusion

Interpretation of results:
relatively harmless
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
2-Chloro-4,6-Dimethoxy-1,3,5-Triazine does not result in mortality of Rabbits with 1000mg/kg bw. no classification for dermal toxicity is necessarry
Executive summary:

Based on the result of this study, the acute dermal Median Lethal Dose (MLD) of 08699 (equivalent to 2-Chloro-4,6-Dimethoxy-1,3,5-Triazine) was estimated to be greater than 1000 mg/kg in the rabbit. The calculated primary irritation indes was 6.33 which classifies this dose level as a severe irritant to the dermal tissue of the rabbit.