Alcohols, C12-14-secondary, .beta.-(2-hydroxyethoxy)

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: Guideline study (OECD) (test substance purity not specified).

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1997

Report date:

1997

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Version / remarks:

, adopted 24 Feb 1987

Test guideline 2

Qualifier:

according to guideline

Guideline:

EU Method B.1 (Acute Toxicity (Oral))

Version / remarks:

, adopted 31 July 1992

GLP compliance:

yes (incl. QA statement)

Remarks:

ToxLabs Prüflabor GmbH

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Alcohols, C12-14-secondary, β-(2-hydroxyethoxy)

EC Number:

308-219-6

EC Name:

Alcohols, C12-14-secondary, β-(2-hydroxyethoxy)

Cas Number:

97926-05-1

IUPAC Name:

97926-05-1

Test material form:

other: liquid

Details on test material:

- Name of test material (as cited in study report): Epicol G24 G2, C12/14alpha-Epoxid, ringgeöffnet mit Glykol, SAT 970397
- Physical state: colorless liquid
- Analytical purity: not specified
- Lot/batch No.: 10017020
- Expiration date of the lot/batch: 1998-01-20
- Storage condition of test material: room temperature in a closed vessel

Test animals

Species:

rat

Strain:

Wistar

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Charles River Wiga GmbH, Germany
- Age at study initiation: 40 - 44 days
- Weight at study initiation: mean body weight: male: 195.5 g ± 9.3 g, female: 157.4 g ± 8.3 g
- Fasting period before study: 16 hours before application and 3 hours after
- Housing: in Makrolon Type 3 cages, 1 animal per cage
- Diet: Altromin Laboratory Standard diet for rats and mice, ALTROMIN 1326, ad libitum
- Water: Community Tap water in Makrolon water bottles, ad libitum
- Acclimation period: 7 days

ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 - 25 °C
- Humidity (%): 50 -70 %
- Photoperiod (hrs dark / hrs light): 12/12

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

unchanged (no vehicle)

Details on oral exposure:

MAXIMUM DOSE VOLUME APPLIED: 0.22 mL/100g body weight

Doses:

2000 mg/kg bw

No. of animals per sex per dose:

5

Control animals:

yes

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: continously on the day of observation and once daily thereafter
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 2 000 mg/kg bw

Based on:

test mat.

Remarks on result:

other: no mortalities were observed

Mortality:

The control and also the treated animals showed no mortality in the course of investigation.

Clinical signs:

other: The control and also the treated animals showed no clinical signs in the course of investigation.

Gross pathology:

There were no substance dependent macroscopic pathological findings in the control and the treated animals.

Applicant's summary and conclusion

Interpretation of results:

not classified

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

DSD: not classified
CLP: not classified