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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)

Data source

Referenceopen allclose all

Reference Type:
review article or handbook
Title:
Acute toxicity data for cas no.121-57-3
Author:
Patty, F. A.
Year:
1967
Bibliographic source:
Industrial Hygiene and Toxicology 1967, 2, Interscience Publishers, New York, NY, USA.
Reference Type:
review article or handbook
Title:
DOSE: S138
Author:
RSC Publishing
Year:
2011
Bibliographic source:
Dictionary of Substances and their effects (DOSE): Patty, F. A. Industrial Hygiene and Toxicology 1967, 2, Interscience Publishers, New York, NY, USA.

Materials and methods

Principles of method if other than guideline:
The acute toxicity study was conducted to evaluate the toxic effects of administration of sulphanilic acid to mouse by the oral route.
GLP compliance:
not specified
Test type:
standard acute method

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report):sulphanilic acid
- Substance type:Organic

Test animals

Species:
mouse
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 3 200 mg/kg bw
Based on:
test mat.
Remarks on result:
other: sulphanilic acid does not exhibits acute toxicity by the oral route.
Mortality:
Lethal dose ; 50 percent kill

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The acute oral median lethal dose (LD50) of sulphanilic acid in mouse was found to be >3200 mg/kg of body weight. Acute toxicity of sulphanilic acid to mouse indicates that sulphanilic acid does not exhibits acute toxicity by the oral route.
Executive summary:

The acute oral median lethal dose (LD50) of sulphanilic acid in mouse was found to be >3200 mg/kg of body weight. Acute toxicity of sulphanilic acid to mouse indicates that sulphanilic acid does not exhibits acute toxicity by the oral route.