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Ecotoxicological information

Toxicity to microorganisms

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Description of key information

The growth inhibition concentration (IGC50) value of 2-aminobenzenesulphonic acid in microorganism (Tetrahymena pyriformis) in a 48 hr study on the basis of growth inhibition effect was estimated to be 219.2835 mg/L.

Key value for chemical safety assessment

EC50 for microorganisms:
219.28 mg/L

Additional information

No. of studies were reviewed for toxicity to microorganisms from reliable sources having Klimisch rating 2 and 4.

The summary of the results are presented below    

Sr.No

Endpoint

Effect values

Basis for effects

Duration

Species

Sources

1.

IGC50

219.2835 mg/L

growth inhibition

48 hrs.

Tetrahymena pyriformis

Predicted data from QSAR for target CAS:88-21-1

2.

IGC50

606.07 mg/L

growth inhibition

46 hrs.

Tetrahymena pyriformis

Predicted data from Danish QSAR for target CAS:88-21-1

3.

EC50

114 mg/L

-

5 min.

Photobacterium phosphoreum

Experimental data from water pollution research journal Canada for read across CAS: 121-57-3

4

IC50

533 mg/L

-

-

Saccharomyces cerevisiae

Experimental data from Methods & Findings in Experimental & Clinical Pharmacology for read across CAS: 121-57-3

 

Based on the studies summarized in the above table for the target substance 2-aminobenzenesulphonic acid and read across substance, the endpoint value was found to be EC50 = 114 mg/L in 5 min.; IGC50 = 219.2835 mg/L to 606.07 mg/L in 46 hrs. to 48 hrs. and IC50 =533 mg/L on the basis of growth inhibition effect.