Registration Dossier
Registration Dossier
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EC number: 200-887-6 | CAS number: 75-63-8
Developmental toxicity / teratogenicity
Administrative data
- Endpoint:
- developmental toxicity
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Not published report
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 414 (Prenatal Developmental Toxicity Study)
- Deviations:
- yes
- Remarks:
- treatment from day 6 to 15 of the gestation
Test material
- Reference substance name:
- Bromotrifluoromethane
- EC Number:
- 200-887-6
- EC Name:
- Bromotrifluoromethane
- Cas Number:
- 75-63-8
- Molecular formula:
- CBrF3
- IUPAC Name:
- bromotrifluoromethane
- Reference substance name:
- bromotrifluorane
- IUPAC Name:
- bromotrifluorane
Constituent 1
Constituent 2
Results and discussion
Results (fetuses)
Fetal abnormalities
- Abnormalities:
- not specified
Overall developmental toxicity
- Developmental effects observed:
- not specified
Applicant's summary and conclusion
- Executive summary:
Exposure of pregnant rats to Halon 1301 vapors from day six through fifteen of gestation at levels of 1000, 10,000 and 50,000 ppm had no effect on their body weight gains. No compound-related clinical signs of toxicity or changes in behavior were noted.
The outcome of pregnancy measured by the number of implantation sites, resorptions and live fetuses, was not adversely affected by the exposure. Exposure did not affect embryonal development as measured by weight and crown-rump length of the fetuses. Only three fetuses, each one from different litter, were found with malformations. All three were from dams exposed to the intermediate level (10,000 ppm) of Halon 1301. These defects were not treatment-related. They are considered as spontaneous, congenital malformations of genetic origin seen in this strain of rats at about the same frequency as in this study.
Under the conditions of this test, Halon 1301 was not embryo-toxic or teratogenic when inhaled by pregnant ChR-CD rats.
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