Registration Dossier
Registration Dossier
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EC number: 484-460-1 | CAS number: 37859-55-5
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Data waiving:
- study technically not feasible
- Justification for data waiving:
- other:
- Reason / purpose for cross-reference:
- data waiving: supporting information
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Details on results:
- The test substance shows quick hydrolysis in aqueous solutions (half life time< 4 minutes). The shake flask method, the HPLC method and the Estimation method are therefore not applicable for determination of the partition coefficient. Calculation of the partition coefficient using the Rekker calculation method is not applicable since silicum containing fragments are not included in this method.
- Conclusions:
- The test substance shows quick hydrolysis in aqueous solutions (half life time< 4 minutes) therefore the partition coefficient cannot be determined.
- Executive summary:
The test substance shows quick hydrolysis in aqueous solutions (half life time< 4 minutes). The shake flask method, the HPLC method and the Estimation method are therefore not applicable for determination of the partition coefficient. Calculation of the partition coefficient using the Rekker calculation method is not applicable since silicum containing fragments are not included in this method.
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- Conducted with the main hydrolysis product= MPKO.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Deviations:
- not specified
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Deviations:
- not specified
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- ca. 1.25
- Temp.:
- 22 °C
- pH:
- ca. 7
- Conclusions:
- The partition coefficient of MPKO was determined to be 1.25 at 22°C (pH 7).
- Executive summary:
The log Pow of MPKO was determined by means of HPLC at neutral pH in accordance with OECD Guideline 107 and EU Method A.8. The following values were determined: Major component peak 1 has a log Pow of 1.2 (Pow = 1.6 x 10). Major component peak 2 has a log Pow of 1.6 (Pow = 2.1 x 10)
Referenceopen allclose all
Neutral pH |
Neutral pH |
|
Pow |
log Pow |
|
Major component peak 1 |
1.6 x 10 |
1.2 |
Major component peak 2 |
2.1 x 10 |
1.3 |
Description of key information
The test substance hydrolyses quickly (half life time < 4 minutes) therefore the partition coefficient cannot be determined. The partition coefficient of MPKO, the hydrolysis product of OS1600, was determined to be 1.25 at 22°C (pH 7)
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 1.25
- at the temperature of:
- 22 °C
Additional information
Data waiving (study technically not feasible): The test substance hydrolyses quickly (half life time < 4 minutes) and therefore, the partition coefficient cannot be determined.
Supporting study: The log Pow of the analogue substance MPKO was determined by means of HPLC at neutral pH in accordance with OECD Guideline 107 and EU Method A.8. The partition coefficient of MPKO was determined to be 1.25 at 22°C (pH 7).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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