Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Long-term toxicity to aquatic invertebrates

Administrative data

Endpoint:
long-term toxicity to aquatic invertebrates
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Guideline study with acceptable restrictions (non-GLP)

Data source

Reference
Reference Type:
secondary source
Title:
Unnamed
Year:
1992

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 211 (Daphnia magna Reproduction Test)
Version / remarks:
Cited as OECD Guide-line 202, part 2 (Daphnia sp., Reproduction Test)
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Lactonitrile
EC Number:
201-163-2
EC Name:
Lactonitrile
Cas Number:
78-97-7
Molecular formula:
C3H5NO
IUPAC Name:
2-hydroxypropanenitrile
Details on test material:
2-Hydroxypropanenitrile
Purity: 92.3 %

Sampling and analysis

Analytical monitoring:
no

Test organisms

Test organisms (species):
Daphnia magna

Results and discussion

Effect concentrationsopen allclose all
Duration:
21 d
Dose descriptor:
EC50
Effect conc.:
0.67 mg/L
Duration:
21 d
Dose descriptor:
NOEC
Effect conc.:
0.17 mg/L
Basis for effect:
reproduction
Duration:
21 d
Dose descriptor:
LOEC
Effect conc.:
0.56 mg/L

Any other information on results incl. tables

RS-Freetext:
Mortality
LC50 (24 h) = 4.8 mg/L (95% confidence level: 2.8-11 mg/L)
LC50 (48 h) = 2.5 mg/L (95% conifidence level: 1.6-4.8 mg/L)
LC50 (96 h) = 1.9 mg/L (95% confidence level: 1.3-3.1 mg/L)
LC50 (7 d) = 1.4 mg/L (95% confidence level: 0.96-2.1 mg/L)
LC50 (14 d) = 0.84mg/L (95% confidence level: 0.62-1.2 mg/L)
LC50 (21 d) = 0.71mg/L (95% confidence level: 0.52-0.98 mg/L)
NOEC =
LOEC =

Reproduction
EC50 (14 d) = 0.78mg/L (95% confidence level: 0.5-1.2 mg/L)
EC50 (21 d) = 0.67mg/L (95% confidence level: 0.49-0.93 mg/L)
NOEC = 0.17mg/L (p <0.05)
LOEC = 0.56mg/L (p <0.05)

Applicant's summary and conclusion