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EC number: 278-388-8 | CAS number: 76199-85-4
Nanomaterial aspect ratio / shape
Administrative data
- Endpoint:
- nanomaterial aspect ratio/shape
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2020
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
Data source
Reference
- Reference Type:
- other: unpublished study report
- Title:
- Unnamed
- Year:
- 2 020
- Report date:
- 2020
Materials and methods
- Principles of method if other than guideline:
- Method selection according to Gaillard et al., Nanoscale Adv., 2019, 1, 781
- GLP compliance:
- no
- Type of method:
- transmission electron microscopy
- Details on methods and data evaluation:
- TEM image evaluation according to Verleysen et al., Materials 2019, 12, 2274; doi:10.3390/ma12142274
Sample preparation: Dispersion in ethanol; transfer to carbon-coated TEM-grids.
Test material
- Reference substance name:
- 2-cyano-2-[2,3-dihydro-3-(tetrahydro-2,4,6-trioxo-5(2H)-pyrimidinylidene)-1H-isoindol-1-ylidene]-N-methylacetamide
- EC Number:
- 278-388-8
- EC Name:
- 2-cyano-2-[2,3-dihydro-3-(tetrahydro-2,4,6-trioxo-5(2H)-pyrimidinylidene)-1H-isoindol-1-ylidene]-N-methylacetamide
- Cas Number:
- 76199-85-4
- Molecular formula:
- C16H11N5O4
- IUPAC Name:
- 2-cyano-N-methyl-2-[3-(2,4,6-trioxotetrahydropyrimidin-5(2H)-ylidene)-2,3-dihydro-1H-isoindol-1-ylidene]acetamide
- Test material form:
- solid: nanoform
Constituent 1
Data gathering
- Instruments:
- TEM: Thermo-Fisher Talos 200 kV
Results and discussion
Shape description
- Key result
- Shape:
- spherical
- Remarks on result:
- other: The material is assigned to the “spheroidal” shape category.
Aspect ratio
- Key result
- x Dimension:
- 2
- St. dev.:
- 0.9
- y Dimension:
- 1
- Remarks on result:
- other: median (D50)
Any other information on results incl. tables
The number-based concentration of particles with sizes below 100 nm (smallest feret diameter) is 98%. The median (D50) of the particle size is 48,4 nm.
The material is therefore classified as “nano” according to the definition of nanomaterial 2011/696/EU.
Applicant's summary and conclusion
- Conclusions:
- - The particles have a median aspect ratio of 2.0:1
- The shape is “spherical”. The material is assigned to the “spheroidal” shape category.
- The median (D50) of the particle size is 48.4 nm. The number-based concentration of particles below 100 nm (smallest feret diameter) is 98%.
The material is therefore classified as "nano" according to the definition of nanomaterial 2011/696/EU.
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