Registration Dossier
Registration Dossier
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EC number: 941-031-8 | CAS number: -
Endpoint summary
Administrative data
Description of key information
Additional information
For the assessment of the aquatic toxicity of "Reaction products of 3-methylbutanal and 3-methylbut-3-en-1-ol after acidic treatment", the two main components with highest potential for aquatic toxicity (5,6-dihydro-4-methyl-2-(2-methylpropyl)-2h-pyran (CAS59848-65-6) and 3,6-dihydro-4-methyl-2-(2-methylpropyl)-2h-pyran (CAS 59848-69-0) have been assessed.
Together, both components make up to 80 % of the substance and are considered to be of most relevance for the environmental hazard assessment based on a QSAR-toxicity-screening of all components.
Based on a ECOSAR calculation for the main components, fish is the most sensitive endpoint. Accordingly, the hazard assessment is based on fish toxicity only to adress the most sensitive endpoint for both components. The final assessment has been accomplished by the use of the OECD-QSAR-Toolbox using a trend analysis.
In Article 13 of Regulation (EC) No 1907/2006, it is laid down that information on intrinsic properties of substances may be generated by means other than tests, provided that the conditions set out in Annex XI (of the same Regulation) are met. Furthermore according to Article 25 of the same Regulation testing on vertebrate animals shall be undertaken only as a last resort.
According to Annex XI of Regulation (EC) No 1907/2006 (Q)SAR results can be used if (1) the scientific validity of the (Q)SAR model has been established, (2) the substance falls within the applicability domain of the (Q)SAR model, (3) the results are adequate for the purpose of classification and labeling and/or risk assessment and (4) adequate and reliable documentation of the applied method is provided.
Based on the Trend analysis (OECD Toolbox) as well as the ECOSAR calculations for the two main components, "Reaction products of 3-methylbutanal and 3-methylbut-3-en-1-ol after acidic treatment" is acutely very toxic to aquatic organisms.
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