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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

The acute oral median lethal dose (LD50) of (3-aminophenyl)uronium chloride in Rat (Wistar) was estimated to be 2680.05 mg/kg bw. This value indicates that (3-aminophenyl)uronium chloride does not exhibits acute toxicity by the oral route in accordance to the criteria laid down by the CLP regulation. 

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records
Reference
Endpoint:
acute toxicity: oral
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6
Qualifier:
equivalent or similar to guideline
Guideline:
other: OECD Guideline 401 (Acute Oral Toxicity)
Principles of method if other than guideline:
Prediction is done using QSAR Toolbox version 3.1
GLP compliance:
no
Test type:
standard acute method
Species:
rat
Strain:
New Zealand White
Sex:
male/female
Route of administration:
oral: gavage
Vehicle:
not specified
No. of animals per sex per dose:
5 animals per sex per dose
Sex:
male/female
Dose descriptor:
LD50
Effect level:
2 680.05 mg/kg bw
Based on:
test mat.





The prediction was based on dataset comprised from the following descriptors: LD50
Estimation method: Takes average value from the 6 nearest neighbours
Domain  logical expression:Result: In Domain

(("a" and "b" )  and ("c" and "d" )  )

Domain logical expression index: "a"

Referential boundary: The target chemical should be classified as Anilines (Acute toxicity) by US-EPA New Chemical Categories

Domain logical expression index: "b"

Similarity boundary:Target: c1(N)cc(N{+}(.Cl{-})=C(N)O)ccc1
Threshold=40%,
Dice(Atom centered fragments)

Domain logical expression index: "c"

Parametric boundary:The target chemical should have a value of logP Multicase which is >= -0.302

Domain logical expression index: "d"

Parametric boundary:The target chemical should have a value of logP Multicase which is <= 1.83

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The acute oral median lethal dose (LD50) of (3-aminophenyl)uronium chloride in Rat (Wistar) was estimated to be 2680.05 mg/kg bw. This value indicates that (3-aminophenyl)uronium chloride does not exhibits acute toxicity by the oral route in accordance to the criteria laid down by the CLP regulation.
Executive summary:

The acute oral median lethal dose (LD50) of (3-aminophenyl)uronium chloride in Rat (Wistar) was estimated to be 2680.05 mg/kg bw. This value indicates that (3-aminophenyl)uronium chloride does not exhibits acute toxicity by the oral route in accordance to the criteria laid down by the CLP regulation.

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
LD50
Value:
2 680.05 mg/kg bw
Quality of whole database:
Model considered reliable by OECD

Additional information

The acute oral median lethal dose (LD50) of (3-aminophenyl)uronium chloride in Rat (Wistar) was estimated to be 2680.05 mg/kg bw. This value indicates that (3-aminophenyl)uronium chloride does not exhibits acute toxicity by the oral route in accordance to the criteria laid down by the CLP regulation.


Justification for selection of acute toxicity – oral endpoint
Model considered reliable by OECD

Justification for classification or non-classification

(3-aminophenyl)uronium chloride is not expected to cause acute toxicity by the oral route.