Registration Dossier
Registration Dossier
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EC number: 260-330-8 | CAS number: 56677-60-2
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: OECD guideline study conducted according to GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 011
- Report date:
- 2011
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
- GLP compliance:
- yes (incl. QA statement)
- Type of study:
- mouse local lymph node assay (LLNA)
Test material
- Reference substance name:
- Tetradecyl chloroformate
- EC Number:
- 260-330-8
- EC Name:
- Tetradecyl chloroformate
- Cas Number:
- 56677-60-2
- Molecular formula:
- C15H29ClO2
- IUPAC Name:
- tetradecyl carbonochloridate
Constituent 1
In vivo test system
Test animals
- Species:
- mouse
- Strain:
- CBA
- Sex:
- female
Study design: in vivo (LLNA)
- Vehicle:
- acetone/olive oil (4:1 v/v)
- Concentration:
- 0, 1.0, 2.5, and 5.0%
- No. of animals per dose:
- 5
Results and discussion
In vivo (LLNA)
Resultsopen allclose all
- Parameter:
- SI
- Remarks on result:
- other: 0%: 1.00 1.0%: 0.80 2.5%: 1.91 5%: 8.56
- Parameter:
- other: disintegrations per minute (DPM)
- Remarks on result:
- other: 0%: 654.3 1.0%: 521.7 2.5%: 1252.3 5%: 5603.9
Applicant's summary and conclusion
- Interpretation of results:
- sensitising
- Remarks:
- Migrated information
- Conclusions:
- The test item Myristyl chloroformate was found to be a skin sensitiser under the test conditions of this study.
- Executive summary:
In order to study a possible skin sensitisation potential of Myristyl chloroformate, three groups each of five female mice were treated daily with the test item at concentrations of 1, 2.5, and 5% (w/v) in acetone:olive oil (4+1 v/v) by topical application to the dorsum of each ear once daily for three consecutive days. All treated animals survived the scheduled study period and no signs of systemic toxicity or local skin irritation were observed.
In this study Stimulation Indices (S.I.) of 0.80, 1.91, and 8.56 were determined with the test item at concentrations of 1, 2.5, and 5 % (w/v) in acetone:olive oil (4+1 v/v), respectively. A clear dose response was observed. The EC3 value calculated was 2.9% (w/v).
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