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EC number: 260-330-8 | CAS number: 56677-60-2
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Parent compound tetradecyl chloroformate: no data available.
Hydrolysis product tetradecanol: no data available; based on mortality results of long-term study: not harmful to aquatic invertrebrates (no mortality/immobility at maximum water solubility).
Hydrolysis product HCL: acutely very toxic for aquatic invertebrates (pH-dependent).
Key value for chemical safety assessment
Additional information
Parent compound tetradecyl chloroformate:
There are no data available concerning the parent compound. Dissolved tetradecyl chloroformate (CAS 56677 -60 -2) rapidly hydrolyse to tetradecanol (CAS 112 -72 -1), CO2 (CAS 124 -38 -9) and HCL (CAS 7647 -01 -0). Therefore read across was made to the main hydrolysis product tetradecanl.
Tetradecanol:
No short-term toxicity data are available for tetradecanol. However, a long-term toxicity study performed according to OECD 211 under GLP conditions is available. The study was performed as 21 -day semi-static test with daily renewal of test substance. Regarding the parent organisms, no animals died up to the second highest concentration of 185 µg/L (nominal value), which is similar to the maximum water solubility. At the highest nominal concentration of 500 µg/L, 30% of the parent animals died. Analytical monitoring of this concentration revealed a mean initial concentration of 367 µg/L and a 21-d mean measured concentration of 76.7 µg/L. Taking into account the maximum water solubility, the long study period and the daily renewal of the test subtance, it can be concluded that the substance is acutely not harmful to aquatic invertebrates (no mortality at maximum water solubility).
As reported in the SIAR for Long Chain Alcohols (OECD, 2006), the toxicity of alcohols increase from an EC50 of 200 mg/L for C6 to 0.77 mg/L for C12. Effects have also been observed in test with C13 and C14 alcohols but at concentrations that exceeded the solubility of the alcohols. Although not explicitly identified in the report, physical effects (rather than true toxicity) can therefore not be excluded from the interpretation of the results for these two alcohols.
The results of the C14 alcohol indicate, that both the parent compound tetradecyl chloroformate and its main hydrolysis product tetradecanol are not harmful to aquatic invertebrates up to their maximum water solubility.
Hydrolysis producthydrochloric acid (HCl):
The hydrolysis product hydrochloric acid (HCl) was tested in a semi-static acute toxicity test according to OECD 202 with Daphnia magna. The 48-h EC50 was 0.492 mg/L (acid equivalent to pH 5.3; OECD, 2002).
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