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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1967

Materials and methods

Principles of method if other than guideline:
Aqueous solutions of test substance administered in single doses to groups of rats of both sexes by oral intubation. Animals were observed for 7 days after treatment and autopsy was carried out on those animals which died during this period and on randomly selected survivors at 7 days. Acute LD50 values with 95 % confidence limits were calculated by the method of Weil (1952).
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Reference substance name:
Acid Red 018
IUPAC Name:
Acid Red 018

Test animals

Species:
other: rat and mouse
Strain:
other: Carworth Farm Strain E SPF (rat) and ICI Alderley Park Strain 1 SPF (mouse)
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water
Doses:
Up to 8000 mg/kg
No. of animals per sex per dose:
5/rat/sex/dose
5/mouse/sex/dose
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 7 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, colouration

Results and discussion

Effect levelsopen allclose all
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 8 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: rat and mouse
Sex:
male/female
Dose descriptor:
LD0
Effect level:
8 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: rat and mouse
Mortality:
No
Clinical signs:
other: No toxic signs. Lethargy for a few hours after dosing.
Other findings:
Slight colouration of animals; coloured material mainly excreted in faeces and to a small extent in urine.

Applicant's summary and conclusion

Interpretation of results:
other: not classified according to the CLP Regulation (EC 1272/2008)
Conclusions:
LD50 > 8000 mg/kg in rat and mouse
Executive summary:

Method

Acute toxicity in rat and mouse dosed up to 8000 mg/kg by gavage. Observation up to 7 days and necropsy of survivors randomly selected.

Results

No deaths; lethargy for a few hours; colouration of faeces and urine.

LD50 > 8000 mg/kg.

LD0 = 8000 mg/kg.