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Ecotoxicological information

Short-term toxicity to fish

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Administrative data

Endpoint:
short-term toxicity to fish
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Published public domain study, limited information regarding methods available

Data source

Reference
Reference Type:
publication
Title:
Results of the investigation of 200 chemical compounds for acute fish toxicity with the Golden Orfe test [Ergebnisse der Untersuchung von 200 chemischen Vergindungen auf akute Fischtoxizitat mit dem Goldorfentest]
Author:
Juhnke, I. & Ludemann, D.
Year:
1978
Bibliographic source:
Zeitschrift fuer Wasser und Abwasser Forschung 11(5): 161-164

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: German Unified Methods for Investigation of Water, Wastewater and Sludge. L15. Fish test. Vom Wasser 46:291-295(1976)
Principles of method if other than guideline:
Acute toxicity to freshwater fish
GLP compliance:
no

Test material

Constituent 1
Reference substance name:
Urea
EC Number:
200-315-5
EC Name:
Urea
Cas Number:
57-13-6
IUPAC Name:
urea
Details on test material:
Urea
Specific details on test material used for the study:
Details on properties of test surrogate or analogue material (migrated information):
Not applicable

Sampling and analysis

Analytical monitoring:
not specified
Details on sampling:
No information available

Test solutions

Vehicle:
not specified
Details on test solutions:
No information available

Test organisms

Test organisms (species):
Leuciscus idus melanotus
Details on test organisms:
Leuciscus idus melanotus; golden orfe

Study design

Test type:
static
Water media type:
freshwater
Total exposure duration:
48 h
Post exposure observation period:
No information available

Test conditions

Hardness:
No information available
Test temperature:
No information available
pH:
No information available
Dissolved oxygen:
No information available
Salinity:
No information available
Nominal and measured concentrations:
No information available
Details on test conditions:
The test was conducted at two different laboratories; the Institute for Water, Soil and Air Hygiene of the Federal Health Office, Berlin; and at the State Institute for Water and Waste, NW.
Reference substance (positive control):
not specified

Results and discussion

Effect concentrationsopen allclose all
Duration:
48 h
Dose descriptor:
LC50
Effect conc.:
> 10 000 mg/L
Nominal / measured:
not specified
Conc. based on:
not specified
Basis for effect:
mortality (fish)
Duration:
48 h
Dose descriptor:
LC0
Effect conc.:
> 10 000 mg/L
Nominal / measured:
not specified
Conc. based on:
not specified
Basis for effect:
mortality (fish)
Details on results:
No information available
Results with reference substance (positive control):
No information available
Reported statistics and error estimates:
No information available

Any other information on results incl. tables

Sublethal observations / clinical signs:

The 48 hour LC50 of urea in golden orfe fish is >10000 mg/l. This can also be considered as the NOEC. The results reported by the two laboratories were identical.

Applicant's summary and conclusion

Validity criteria fulfilled:
not specified
Conclusions:
The 48 hour NOEC of urea in fish >10000 mg/l; urea is not acutely toxic to fish.
Executive summary:

The 48 hour LC50 of urea in golden orfe fish is >10000 mg/l. This can also be considered as the NOEC. The results reported by the two laboratories were identical. It can be concluded that urea is not acutely toxic to fish.