Registration Dossier
Registration Dossier
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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 200-832-6 | CAS number: 75-02-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Specific investigations: other studies
Administrative data
Link to relevant study record(s)
Description of key information
Additional information
Justification for read-across can be found in the supporting documentation (analogue reporting format) attached in IUCLID5.
The substance, vinyl fluoride (VF), is biotransformed by the same metabolic pathway as an extensively studied known human carcinogen, vinyl chloride (VC). The biotransformation proceeds via the cytochrome P450 (CYP) 2E1 pathway, and is followed by interaction with DNA. VC is associated with a very rare angiosarcoma cancer type in humans and cancer in laboratory animals. VF is likewise associated with a similar cancer in laboratory animals. The production of cancer is related to the VC and VF biotransformation products. The biotransformation pathway becomes saturated at concentrations above 75 ppm VF and 250 ppm VC. While VC is biotransformed at a faster rate and to a greater extent, the close structural and chemical similarity as well as behaviour in biological systems, allows for the use of VC (human data and analysis) as a conservative read-across substance in the assessment of VF carcinogenicity. See additional supporting documentation elsewhere in IU5.
Multiple VC epidemiological studies have been conducted, in addition to the conduct of robust VC and VF animal carcinogenicity studies. VC carcinogenic risk evaluations have been conducted using both epidemiological-based and experimental data-based approaches. These are summarized in Scientific Committee on Occupational Exposure Limit (SCOEL) risk assessment for VC. Both approaches produced similar quantitative carcinogenicity risk estimates. Based on the robust VC dataset, it was concluded that continuous exposure throughout a working life to 1 ppm VC would be associated with a cancer risk for hepatic angiosarcoma of 0.3E-3.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.