Fluoroethylene

Neurotoxicity

Administrative data

Endpoint:

neurotoxicity: acute inhalation

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Cross-reference

Reason / purpose for cross-reference:

reference to same study

Data source

Reference

Reference Type:

publication

Title:

Acute and Chronic Toxicity of Some Halogenated Derivatives of Methane and Ethane

Author:

Lester D and Greenberg LA

Year:

1950

Bibliographic source:

Indus. Hyg. Occup. Med., 2:335-344

Materials and methods

Principles of method if other than guideline:

Rats were exposed in airtight glass chambers for up to 30 minutes to concentrations up to 80% by volume and a concentration of 20% oxygen. A few animals were exposed at 80% for 12.5hours. The rats were sacrificed and the lungs examined. Upon removal from the exposure chamber observations were made for loss of postural, righting, and corneal reflexes.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Fluoroethylene

EC Number:

200-832-6

EC Name:

Fluoroethylene

Cas Number:

75-02-5

Molecular formula:

C2H3F

IUPAC Name:

fluoroethene

Details on test material:

Purity: Not reported

Test animals

Species:

rat

Strain:

not specified

Sex:

not specified

Administration / exposure

Route of administration:

inhalation: gas

Analytical verification of doses or concentrations:

no

Duration of treatment / exposure:

up to 30 minutes; a few animals for 12.5 hours

Frequency of treatment:

Once

Doses / concentrations

Remarks:

Doses / Concentrations:
10, 20, 30, 40, 50, 60, 70, and 80%.
Basis:
nominal conc.

Results and discussion

Effect levels

Dose descriptor:

other: neurotoxicity

Sex:

not specified

Basis for effect level:

other: see 'Remark'

Remarks on result:

not measured/tested

Remarks:

Effect level not specified

Any other information on results incl. tables

All animals survived exposure.

Applicant's summary and conclusion

Conclusions:

Rats were slightly intoxicated after inhalation exposure to the test substance for up to 30 minutes at 30% with evidence of hindleg instability. Postural reflex was lost at 60%. At 80% the animals were dyspnoeic, but fully recovered after breathing room air for 1 minute. The corneal reflex was still present in the rats kept at 80% for 12.5 hours. These too recovered their reflexes immediately on being removed to room air.

Executive summary:

Rats were exposed in airtight glass chambers for up to 30 minutes to concentrations up to 80% by volume and a concentration of 20% oxygen. A few animals were exposed at 80% for 12.5 hours. The rats were sacrificed and the lungs examined. Upon removal from the exposure chamber observations were made for loss of postural, righting, and corneal reflexes. All animals survived exposure. Rats were slightly intoxicated at 30% with evidence of hindleg instability. Postural reflex was lost at 60%. At 80% the animals were dyspnoeic, but fully recovered after breathing room air for 1 minute. The corneal reflex was still present in the rats kept at 80% for 12.5 hours. These too recovered their reflexes immediately on being removed to room air. The lungs showed no evidence of irritation.