Registration Dossier
Registration Dossier
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EC number: 247-477-3 | CAS number: 26140-60-3
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxicity and metabolism of ortho-, meta- and para-terphenyls
- Author:
- Cornish HH, Bahor RE, Ryan RC
- Year:
- 1 962
- Bibliographic source:
- American Industrial Hygiene Association Journal, Volume 23, Issue 5, pp 372-378
Materials and methods
- GLP compliance:
- not specified
Test material
- Reference substance name:
- ortho-terphenyl
- IUPAC Name:
- ortho-terphenyl
- Reference substance name:
- meta-terphenyl
- IUPAC Name:
- meta-terphenyl
- Reference substance name:
- para-terphenyl
- IUPAC Name:
- para-terphenyl
Constituent 1
Constituent 2
Constituent 3
Test animals
- Species:
- rat
Administration / exposure
- Route of administration:
- oral: feed
- Duration and frequency of treatment / exposure:
- - acute studies
- 30 day feeding studies
Results and discussion
Applicant's summary and conclusion
- Executive summary:
The results indicated suggested that continued ingestion (30 -days via food) could result in liver and kidney damage. The major identified metabolites of o- and m-terphenyl are glucosiduronic acids and phenols. Para-terphenyl on the other hand was poorly absorbed and a large proportion of that substance was excreted in the feces.
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