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Physical & Chemical properties

Partition coefficient

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Description of key information

The log Pow of Jeffamine RFD 270 was determined in a GLP study according to OECD Guideline 117 and EC A.8 to be in the range of 1.59 to 3.48 at 20 °C and pH 11.5, following the HPLC method (Tarran, 2012).

Key value for chemical safety assessment

Log Kow (Log Pow):
2.17
at the temperature of:
20 °C

Additional information

The log Pow range represents four peaks observed in the HPLC chromatogram (column temperature: 40°C). Individual log Pow values calculated are: 1.59, 2.29, 2.97 and 3.48 with observed relative peak areas of 49.0%, 25.4%, 14.9% and 10.7%, respectively. Using the measured peak area for each calculated partition coefficient, the weighted mean Log Pow for the test substance is 2.17.

The results are also considered to be applicable at 20°C. The test was performed at pH 11.5 to ensure the substance is predominantly in its non-ionised form. This does not truly reflect physiological and environmental conditions (pH 5-9) at which pH the ionisable groups might be charged and the water solubility increased resulting in a lower octanol/water partition coefficient. In addition, the log Pow was estimated based on atomic or group fragment constants and structural factors to be 1.18 (Younis S, 2012).