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EC number: 245-642-4 | CAS number: 23410-40-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- The study was well documented and meets generally accepted scientific principles, but was not conducted in compliance with GLP. In addition, the following acceptable restrictions are identified: No evidence of replicates or checks against well established references, Loading Concentrations may be approximate, and there are no uncertainties quoted, and LOQ is not stated.
- Principles of method if other than guideline:
- Screening method based on 1H-NMR spectroscopy. The formation of the product methanol was observed.
- GLP compliance:
- no
- Buffers:
- pH 4: citrate buffer, pH 7: phosphate buffer and pH 9: borate buffer
- Preliminary study:
- No preliminary study was carried out.
- Transformation products:
- yes
- No.:
- #1
- No.:
- #2
- Details on hydrolysis and appearance of transformation product(s):
- The formation of methanol and the formation and decay of the mono-methoxy intermediate were followed during the reaction.
- pH:
- 4
- DT50:
- < 3 min
- Remarks on result:
- other: At room temperature
- pH:
- 7
- DT50:
- 15 min
- Remarks on result:
- other: At room temperature
- pH:
- 9
- DT50:
- < 3 min
- Remarks on result:
- other: At room temperature
- Other kinetic parameters:
- None determined.
- Conclusions:
- Hydrolysis half-lives of <3 min at pH 4, 15 min at pH 7 and <3 min at pH 9 were determined at room temperature in a non-guideline study conducted according to generally accepted scientific principles, but not in compliance with GLP.
- Endpoint:
- hydrolysis
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- Please refer to the attached justification for grouping of substances provided in IUCLID Section 13.
- Reason / purpose for cross-reference:
- read-across source
- Transformation products:
- yes
- No.:
- #1
- No.:
- #2
- pH:
- 4
- DT50:
- < 3 min
- Remarks on result:
- other: At room temperature
- pH:
- 7
- DT50:
- 15 min
- Remarks on result:
- other: At room temperature
- pH:
- 9
- DT50:
- < 3 min
- Remarks on result:
- other: At room temperature
Referenceopen allclose all
The NMR experiment allowed the loss of the first methoxy group to be followed and the formation of the monomethoxy-intermediate, which is eventually also hydrolysed. All methoxy groups are ultimately converted to methanol.
Taking into account only the original test substance and final products, a formal half-life of 15 mins was calculated. This corresponds to the slope of the regression line in the Arrhenius plot. It was noted that the axis intercept for this plot was at ca. 70% rather than being close to 100% at time zero. The authors of the report concluded that this probably resulted from fast hydrolysis of the original silane to the mono-methoxy-intermediate, which then hydrolyses much slower. This behaviour was not investigated in more detail because it was clear that hydrolysis was very rapid.
Description of key information
Half-Life time <3 min at pH 4 and 9, 15 min at pH 7 (no guideline, no GLP), RL2
Key value for chemical safety assessment
Additional information
There are no hydrolysis data available for N-[3-(dimethoxymethylsilyl)-2-methylpropyl]ethylenediamine (CAS 23410-40-4) therefore good quality data for the analogue substance, N-[3-(dimethoxymethylsilyl)propyl]ethylenediamine (CAS 3069-29-2) have been read across. Both substances hydrolyse rapidly to comparable hydrolysis products, N-[3-(dihydroxymethylsilyl)-2-methylpropyl]ethylenediamine and N-[3-(hydroxydimethylsilyl)propyl]ethylenediamine. It is therefore considered valid to read-across the results for N-[3-(dimethoxymethylsilyl)-2-methylpropyl]ethylenediamine and N-[3-(dimethoxy methylsilyl)propyl]ethylenediamine to fill the data gap for the registered substance.
Hydrolysis half-lives of <3 min at pH 4, 15 min at pH 7 and <3 min at pH 9 were determined at room temperature in a non-guideline study conducted according to generally accepted scientific principles, but not in compliance with GLP (Degussa Goldschmidt AG, 2006).
The half-life of a substance at pH 2 is calculated based on:
t1/2(pH 2) = t1/2(pH 4) / 100
The calculated half-life of N-[3-(dimethoxymethylsilyl)propyl]ethylenediamine at pH 2 is therefore 5 seconds.
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