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EC number: 203-412-0 | CAS number: 106-58-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- No data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 968
- Report date:
- 1968
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Standardised study to determine the acute toxicity of the test item in mice after single i.p. application.
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- 1,4-dimethylpiperazine
- EC Number:
- 203-412-0
- EC Name:
- 1,4-dimethylpiperazine
- Cas Number:
- 106-58-1
- Molecular formula:
- C6H14N2
- IUPAC Name:
- 1,4-dimethylpiperazine
- Details on test material:
- - Name of test material (as cited in study report): Jeffcat DMP
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): N,N´-Dimethylpiperazin
- Analytical purity: 99 %
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 19-36 g
No further data.
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- water
- Details on exposure:
- No data
- Doses:
- 200, 400, 640, 800 cm³/kg bw (170, 340, 544, 680 mg/kg bw - conversation in mg/kg is based on the density: d= 0.85 g/cm³)
The doses were administered as aqueous solutions of 8% (800 cm³/kg), 4% (400, 640 cm³/kg) and 2% (200 cm³/kg) test substance. - No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 7 days
- Frequency of observations: daily
- Frequency of weighing: before the start of the study
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 544 - < 680 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: Corresponds to 640 and 800 cm³/kg bw; the mg/kg was calculated on the density d= 0.85 g/cm³. 680 mg/kg: all females and 4 males died within 24 hours post application; 544 mg/kg bw: one male and one female animal died within 24 hours post application.
- Mortality:
- 680 mg/kg bw : all female animals and 4 males died within 24 hours post application
544 mg/kg bw : 1 male and 1 female animal died within 24 hours post application
340 mg/kg bw: one female animal died within 7 days post application
No mortalities in the 170 mg/kg bw dose group. - Clinical signs:
- Immediately after application, dyspnoea, tremor, indicated morphine tails, shrunken flanks, high stepping gait, struggles in the 680 mg/kg bw dose group were observed. On the next day, the surviving animals showed clotted eyes, scrubby fur, accelerated respiration. 5 to 6 days after exposure, no clinical signs were observed.
- Body weight:
- no data
- Gross pathology:
- Animals that died: livers were full of blood, intestine and intraperitoneum were reddened
Animals sacrificed at the end of observation period: connation of liver and stomach in 10 animals
Applicant's summary and conclusion
- Conclusions:
- After intraperitoneal administration of the substance to mice, the LD50 was observed to be within the range of 544 and 680 mg/kg bw.
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