Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

Currently viewing:

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
No data
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1968
Report date:
1968

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
Version / remarks:
(adopted on 1981, 12th may; inhalation hazard test)
Deviations:
yes
Remarks:
Animals were observed for only 7 days, no details only animal husbandry, exposure period of 8 hours, concentration of test substance in air mixture was not determined analytically
GLP compliance:
no
Test type:
other: inhalation hazard test (IHT)

Test material

Constituent 1
Chemical structure
Reference substance name:
1,4-dimethylpiperazine
EC Number:
203-412-0
EC Name:
1,4-dimethylpiperazine
Cas Number:
106-58-1
Molecular formula:
C6H14N2
IUPAC Name:
1,4-dimethylpiperazine
Details on test material:
- Name of test material (as cited in study report): Jeffcat DMP
Specific details on test material used for the study:
- Name of test material (as cited in study report): N,N´-Dimethylpiperazin
- Analytical purity: 99 %

Test animals

Species:
rat
Strain:
not specified
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Weight at study initiation: 177 g (mean)

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
not specified
Vehicle:
air
Details on inhalation exposure:
The test demonstrates the toxicity of an atmosphere saturated with vapours of the volatile components of a test substance at the temperature chosen for vapour generation (20 °C). 3 rats (respec. 6 rats in the 8h experiment) per sex were exposed sequentially to the vapours, generated by bubbling 200 l/h air through a substance column of about 5 cm above a fritted glassdisc in a glass cylinder for 1 h, 3 h or 8 h. The documentation of clinical signs was performed over a period of 8 days.
Analytical verification of test atmosphere concentrations:
no
Duration of exposure:
>= 1 - <= 8 h
Remarks on duration:
1 h, 3 h or 8 h exposure
Concentrations:
1 h and 3 h exposure: 17.2 mg/L (mean); no data concerning 8 h exposure.
(nominal concentrations not verified by analytics).
No. of animals per sex per dose:
1 h and 3 h exposure: 6 animals
8 h exposure: 12 animals
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 7 days
- Frequency of observations: daily
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight

Results and discussion

Effect levels
Key result
Sex:
male/female
Dose descriptor:
other: Inhalation Risk Test
Based on:
test mat.
Remarks on result:
other: exposure of 1, 3 or 8 hours (3 h exposure: 1 rat died within 24 hours; 8 h exposure: 1 animal died within the exposure, 9 animals within 24 h and 1 animal within 72 h after exposure)
Mortality:
1 h exposure: no mortality observed.
3 h exposure: 1 rat died within 24 hours.
8 h exposure: 1 animal died within the exposure, 9 animals within 24 h and 1 animal within 72 h after exposure.
Clinical signs:
other: Rats showed escape attempts and signs of severe irritation of the mucous membranes. Bloody snout, nose and eye crusts. Lateral position and tumbling in the 8 h exposure group.
Body weight:
The surviving animals gained weight.
Gross pathology:
1 h exposure: no abnormalities observed.
3 h exposure: 1 animal showed ruffled fur and slight bloody crusts at the muzzle and orbital cavity. 1 animal had pulmonary emphysema with bronchitis.
8 h exposure: animals showed ruffled fur and bloody crust formation at the nose (4x), muzzles and orbital cavity (1x). 2 animals had pulmonary emphysema.

Any other information on results incl. tables

Mortality:

 24 h  7 days
 1 h exposure  0/6  0/6
 3 h exposure  1/6  1/6
 8 h exposure  10/12  11/12

The inhalation of a enriched/saturated vapor-air-mixture caused mortality within 3 h. There is indication that the test substance causes local irritation to exposed tissue including respiratory tract.

Applicant's summary and conclusion

Interpretation of results:
study cannot be used for classification
Conclusions:
The inhalation of a enriched/saturated vapor-air-mixture caused mortality within 3 h. There is indication that the test substance causes local irritation to exposed tissue including respiratory tract.