Registration Dossier
Registration Dossier
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EC number: 700-743-7 | CAS number: 161798-03-4
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 000
- Report date:
- 2000
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
Test material
- Reference substance name:
- ethyl 2-[3-formyl-4-(2-methylpropoxy)phenyl]-4-methyl-1,3-thiazole-5-carboxylate
- EC Number:
- 700-743-7
- Cas Number:
- 161798-03-4
- Molecular formula:
- C18H21NO4S
- IUPAC Name:
- ethyl 2-[3-formyl-4-(2-methylpropoxy)phenyl]-4-methyl-1,3-thiazole-5-carboxylate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- The animals were placed in an environmentally conditioned room with temperature within 22-25ºC, a relative humidity within 50-65%, rrom air ventilation of approximately 15times/hour, and lighting for 12 hours (7:00 - 19:00)
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: 0.5% methylcelullose solution
- Details on oral exposure:
- The animals were daily observed to confirm whether or not they died, for 15 days after the administration, starting from the administration day.
- Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- Ten rats of each sex were divided in two groups of 5 animals and given Isobutyl Derivative at 2000 mg/kg or the vehicle, 0.5% methylcelullose solution by gavage.
Spraque-Dawley rats (Crj: CD; SPF) of both sexes, 4 weeks old. These animals were quanrantined and acclimatized for 7 days. - Control animals:
- yes
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- >= 2 000 mg/kg bw
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Remarks:
- Migrated information
- Conclusions:
- From these results, it is considered that the 50% lethal dose (LD50) for Isobutyl Derivative by gavage in the rat is over 2000 mg/kg
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