Registration Dossier

Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
other: WOE
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)

Data source

Reference
Reference Type:
other: conclusion of WoE Study
Title:
Weight of evidence for eye irritation from MSDS for CAS No.: 98-42-0
Author:
TCI America
Year:
2012
Bibliographic source:
Material safety data sheet - TCI America Portland OR

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other:
Principles of method if other than guideline:
Material safety data sheet - TCI America Portland OR
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Reversibility:
other: unspecified
Remarks on result:
other: Eye contact can result in corneal damage or blindness

Applicant's summary and conclusion

Interpretation of results:
Category 1 (irreversible effects on the eye)
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Eye contact with the substance, 3-amino-4-methoxybenzenesulphonic acid, can result in corneal damage or blindness.
Executive summary:

Since eye contact can result in corneal damage or blindness so it can be infered that the target substance will be corrosive to eye and thus will qualify for classification in category 1 as per the EU classification and labelling inventory. This is also supported by the fact that the target chemical, 3-amino-4-methoxybenzenesulphonic acid, is highly acidic as has been mentioned in the phys chem section of this dossier.