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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
other: WOE
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)

Data source

Reference
Reference Type:
other: conclusion of WoE Study
Title:
Weight of evidence for skin irritation from MSDS for CAS No.: 98-42-0
Author:
TCI America
Year:
2012
Bibliographic source:
Material safety data sheet - TCI America Portland OR

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other:
Principles of method if other than guideline:
Material safety data sheet - TCI America Portland OR
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material: 3-amino-4-methoxybenzenesulphonic acid
- Molecular formula: C7H9NO4S
- Molecular weight: 203.22
- Substance type: organic
- Physical state: Soild

Test animals

Strain:
not specified

Test system

Type of coverage:
other: unspecified
Preparation of test site:
other: unspecified
Vehicle:
unchanged (no vehicle)

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Reversibility:
other: unspecified
Remarks on result:
other: positive

Applicant's summary and conclusion

Interpretation of results:
Category 1 (corrosive)
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
3-amino-4-methoxybenzenesulphonic acid is estimated to be corrosive to skin.
Executive summary:

3-amino-4-methoxybenzenesulphonic acid is observed to be corrosive to skin. Skin contact may produce burns as the pH of the substance indicates that the chemical is acidic in nature. Moreover the analog for the target substance (which have more than 90% similarity) also indicates corrosive characteristics on skin and eye. Thus, based on these evidences it can be infered that the target, 3-amino-4-methoxybenzenesulphonic acid, will be corrosive to skin and so will qualify for classification in category 1