Registration Dossier

Administrative data

Link to relevant study record(s)

Description of key information

Short description of key information on bioaccumulation potential result: 
1,1,1,3,3,3-hexafluoropropane-2-ol was identified as a metabolite of the anaesthetic Sevoflurane in human subjects. 1,1,1,3,3,3-hexafluoropropane-2-ol did not undergo further defluorination but was rapidly conjugated to glucuronic acid and rapidly excreted in the urine.

Key value for chemical safety assessment

Bioaccumulation potential:
no bioaccumulation potential

Additional information

1,1,1,3,3,3 -hexafluoropropane-2 -ol was identified as a metabolite of the anaesthetic Sevoflurane in human subjects. HFIP did not undergo further defluorination but was rapidly conjugated to glucuronic acid and rapidly excreted in the urine. No bioaccumulation is predicted.

Discussion on bioaccumulation potential result:

1,1,1,3,3,3-hexafluoropropane-2-ol

was identified as a metabolite of the anaesthetic Sevoflurane in human subjects. 

1,1,1,3,3,3-hexafluoropropane-2-ol

did not undergo further defluorination but was rapidly conjugated to glucuronic acid and rapidly excreted in the urine. No bioaccumulation is predicted.