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EC number: 244-344-1 | CAS number: 21351-79-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1975
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: No GLP, equivalent or similar to OECD and EU guideline.
Cross-reference
- Reason / purpose for cross-reference:
- reference to other study
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Acute toxicity of cesium and rubidium compounds
- Author:
- Johnson, G.T.; Lewis, R.T. and Wagner, W.D.
- Year:
- 1 975
- Bibliographic source:
- Toxicology and applied pharmacology 32, 239-245 (1975)
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 972
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- not specified
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- Deviations:
- not specified
- GLP compliance:
- no
Test material
- Reference substance name:
- Caesium hydroxide
- EC Number:
- 244-344-1
- EC Name:
- Caesium hydroxide
- Cas Number:
- 21351-79-1
- Molecular formula:
- CsHO
- IUPAC Name:
- caesium hydroxide
- Reference substance name:
- Cesium hydroxide
- IUPAC Name:
- Cesium hydroxide
- Test material form:
- solid: crystalline
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- other: albino
- Details on test animals or test system and environmental conditions:
- no details given
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- other: intact and abraded
- Vehicle:
- water
- Controls:
- other: negative and positive (5% HCl) control animals
- Amount / concentration applied:
- A 5% dillution was applied to the rabbits skin. CsOH was dissolved in deionized-distilled water on a weight-to-weight basis prior to administration.
Application volume: 0.1 mL - Duration of treatment / exposure:
- single treatment
- Observation period:
- 48 h
- Number of animals:
- six rabbits in total (no information on sex)
- Details on study design:
- TEST SITE
- Area of exposure: gauze patch size = 20 mm2
- Type of wrap if used: The test sites were covered with a gauze patch. Each animal was provided with a leather harness to prevent the animal from disturbing the sites.
SCORING SYSTEM:
After 24 h exposure, the harness and patches were removed and the skin reaction were evaluated; a second evaluation was performed 48 h after administration of the compound. The technique employed for determining the degree of the primary skin irritation was a modification of the Draize technique.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Remarks:
- intact skin
- Time point:
- other: 24/48 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Remarks:
- abraded skin
- Time point:
- other: 24/48 h
- Score:
- 1.58
- Max. score:
- 4
- Reversibility:
- no data
- Irritant / corrosive response data:
- CsOH (5%) was considered to be non irritating to the intact skin (overall irritaion score = 0). When applied to the abraded CsOH was considered to be mild irritant (overall irritaion score = 1.58), but has not to be classified accoring to 67/548/EC (DSD) and Regulation (EC) No 127272008 (GHS).
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Cesium hydroxide (5%) was considered to be non irritating to the intact skin of albino rabbits (overall irritaion score = 0). When applied to the abraded CsOH was considered to be mild irritant (overall irritaion score = 1.58), but has not to be classified accoring to 67/548/EC (DSD) and Regulation (EC) No 127272008.
- Executive summary:
In a primary dermal irritation study, albino rabbits (6 animals) were dermally exposed to 0.1 mL of cesium hydroxide (5%) in water. Animals then were observed for 48 hours. Irritation was scored by the method of Draize.
Cesium hydroxide(5%) was considered to be non irritating to the intact skin (overall irritaion score = 0). When applied to the abraded CsOH was considered to be mild irritant (overall irritaion score = 1.58), but has not to be classified accoring to 67/548/EC (DSD) and Regulation (EC) No 1272/2008.
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