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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1975
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: No GLP, equivalent or similar to OECD and EU guideline.
Cross-reference
Reason / purpose:
reference to other study

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Acute toxicity of cesium and rubidium compounds
Author:
Johnson, G.T.; Lewis, R.T. and Wagner, W.D.
Year:
1975
Bibliographic source:
Toxicology and applied pharmacology 32, 239-245 (1975)
Reference Type:
publication
Title:
Unnamed
Year:
1972

Materials and methods

Test guidelineopen allclose all
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
Deviations:
not specified
Qualifier:
equivalent or similar to
Guideline:
EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
Deviations:
not specified
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Test material form:
solid: crystalline

Test animals

Species:
rabbit
Strain:
other: albino
Details on test animals and environmental conditions:
no details given

Test system

Type of coverage:
semiocclusive
Preparation of test site:
other: intact and abraded
Vehicle:
water
Controls:
other: negative and positive (5% HCl) control animals
Amount / concentration applied:
A 5% dillution was applied to the rabbits skin. CsOH was dissolved in deionized-distilled water on a weight-to-weight basis prior to administration.
Application volume: 0.1 mL
Duration of treatment / exposure:
single treatment
Observation period:
48 h
Number of animals:
six rabbits in total (no information on sex)
Details on study design:
TEST SITE
- Area of exposure: gauze patch size = 20 mm2
- Type of wrap if used: The test sites were covered with a gauze patch. Each animal was provided with a leather harness to prevent the animal from disturbing the sites.

SCORING SYSTEM:
After 24 h exposure, the harness and patches were removed and the skin reaction were evaluated; a second evaluation was performed 48 h after administration of the compound. The technique employed for determining the degree of the primary skin irritation was a modification of the Draize technique.

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
overall irritation score
Basis:
mean
Remarks:
intact skin
Time point:
other: 24/48 h
Score:
0
Max. score:
4
Reversibility:
other: not applicable
Irritation parameter:
overall irritation score
Basis:
mean
Remarks:
abraded skin
Time point:
other: 24/48 h
Score:
1.58
Max. score:
4
Reversibility:
no data
Irritant / corrosive response data:
CsOH (5%) was considered to be non irritating to the intact skin (overall irritaion score = 0). When applied to the abraded CsOH was considered to be mild irritant (overall irritaion score = 1.58), but has not to be classified accoring to 67/548/EC (DSD) and Regulation (EC) No 127272008 (GHS).

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Cesium hydroxide (5%) was considered to be non irritating to the intact skin of albino rabbits (overall irritaion score = 0). When applied to the abraded CsOH was considered to be mild irritant (overall irritaion score = 1.58), but has not to be classified accoring to 67/548/EC (DSD) and Regulation (EC) No 127272008.
Executive summary:

In a primary dermal irritation study, albino rabbits (6 animals) were dermally exposed to 0.1 mL of cesium hydroxide (5%) in water. Animals then were observed for 48 hours. Irritation was scored by the method of Draize.

Cesium hydroxide(5%) was considered to be non irritating to the intact skin (overall irritaion score = 0). When applied to the abraded CsOH was considered to be mild irritant (overall irritaion score = 1.58), but has not to be classified accoring to 67/548/EC (DSD) and Regulation (EC) No 1272/2008.