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EC number: 204-008-7 | CAS number: 112-82-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
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- Flash point
- Auto flammability
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- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
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- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
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- Nanomaterial surface chemistry
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- Endpoint summary
- Stability
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- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
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- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
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- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 18th June 2002 to 02 July 2002
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Study conducted in compliance with agreed protocols, with no deviations from standard test guidelines and no methodological deficiencies, which do not affect the quality of the relevant results. The study report was conclusive, done to a valid guideline and the study was conducted under GLP conditions.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 003
- Report date:
- 2003
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.3 (Acute Toxicity (Dermal))
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 1-bromohexadecane
- EC Number:
- 204-008-7
- EC Name:
- 1-bromohexadecane
- Cas Number:
- 112-82-3
- Molecular formula:
- C16H33Br
- IUPAC Name:
- 1-bromohexadecane
- Details on test material:
- - Substance type: White semi-solid block on arrival, which subsequently melts into a clear colourless liquid.
- Date received: 12th April
- Storage condition of test material: Room temperature, in the dark.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River (UK) Ltd., Margate, Kent, UK.
- Age at study initiation: 8-12 weeks.
- Weight at study initiation: at least 200g
- Housing: Housed in suspended soil-floor polypropylene cages. Animals were housed individually during exposure then in groups of 5, by sex, for the remainder of the study.
- Diet (e.g. ad libitum): Certified Rat and Mouse Diet (Code 5LF2) supplied by Nutrition International, Nottingham, UK and IPS Product Supplies Ltd, Northants, UK. Food was provided ad libitum throughout the study.
- Water (e.g. ad libitum): Mains drinking water ad libitum.
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature: 19-25°C
- Humidity: 30-70%
- Air changes: 15 per hr
- Photoperiod (hrs dark / hrs light): 12 hrs of light from 06:00 to 18:00, then 12 hrs of dark.
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: Back and flanks of the animals were used for exposure.
- % coverage: 10% of the total body surface
- Type of wrap if used: Surgical gauze attached with self-adhesive bandage.
TEST MATERIAL
- Test material was used as supplied.
- Volume: 2.01 ml/kg
REMOVAL OF TEST SUBSTANCE
- Washing (if done): Residue was removed with cotton wool moistened with distilled water.
- Time after start of exposure: 24 hrs. - Duration of exposure:
- 24 hr
- Doses:
- 2000 mg/kg body wieght
- No. of animals per sex per dose:
- 5 males and 5 females
- Control animals:
- no
- Details on study design:
- - Observations were made for deaths and signs of toxicity. At 30 minutes, 1, 2 and 4 hours post exposure, then daily for 14 days.
- Primary irritation was observed after patch removal then once daily for the 14 day observation period. Skin was scored according to the Draize scale (1977). The scoring system can be seen in table 1 in the field "Any other information on materials and methods incl. tables". Any other skin reactions were also recorded.
- Necropsy of survivors performed: yes
- Other examinations performed: body weight, macroscopic examination, internal examination of the abdominal and thoracic cavities.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No deaths occurred.
- Clinical signs:
- other: No signs of systemic toxicity.
- Gross pathology:
- No abnormalities were noted at necropsy.
- Other findings:
- Very slight or well-defined erythema and crust formation were noted at the treatment sites of all animals. Very slight oedema was also noted at the treatment sites of two males. Treatment sites appeared normal eight to ten days after dosing.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Under the conditions of the test, the acute dermal toxicity of the test material was determined to be LD50 > 2000 mg/kg.
- Executive summary:
The acute dermal toxicity of the test material was determined in a GLP-compliant study according to OECD Guideline 402 and EU Method B.3. Ten Sprague Dawley rats were exposed to the test material for period of 24 hours, the test animals were then observed over a period of 14 days. The LD₅₀ of the test material was determined to be > 2000 mg/kg of body weight. During the observation period no mortalities were seen and no other systematic signs of toxicity were reported.
The test material does not require classification according to Regulation 1272/2008.
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