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Diss Factsheets
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EC number: 700-080-3 | CAS number: 752225-55-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2008
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: according to guideline and GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 008
- Report date:
- 2008
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- not specified
- GLP compliance:
- yes
Test material
- Reference substance name:
- Soybean oil, epoxidized, reaction products with methanol, hydrolyzed, polymerized
- IUPAC Name:
- Soybean oil, epoxidized, reaction products with methanol, hydrolyzed, polymerized
- Details on test material:
- Lot/Batch: 08097
The substance was tested by the test house using a trade name that is considered confidential business information. The name assigned to the substance has therefore been changed to Cargill BP-A.
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- Animals Used in the Study:
Number and Species: 3 New Zealand White rabbits (Oryctolagus cuniculus)
Sex: 1 male and 2 females (females were nonpregnant and nulliparous)
Weight/Age Range: 2.16 2.36 kilograms / at least 10 weeks old (adult) weighed to the nearest 10 g
Health Status: healthy, not previously used in other experimental procedures
Animal Purchase: Millbrook Breeding Labs, Amherst, MA
Animal Identification: ear marker
Acclimation: minimum 5 days, under same conditions as for the actual test
Animal Selection: selected from larger pool and examined to ensure lack of adverse clinical signs
Animal Care and Maintenance:
Animal Room Temperature: 68 ± 5 °F
Animal Room Relative Humidity: 30 70%
Air Exchanges per Hour: a minimum of 10 changes per hour
Lights: 12hour light/dark cycle, full spectrum fluorescent lights
Housing: individually housed
Cages: suspended stainless steel
Bedding: hardwood chips, P.W.I. Industries, StHyacinthe, Quebec, Canada (noncontact)
Animal Rations: TEK Hi-Fiber Rabbit Diet 2031, Harlan Teklad, Madison, WI, ad libitum
Water: tap water, ad libitum
There will be no known contaminants present in the feed, water, or bedding expected to interfere with the test data.
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 0.4 mL
- Duration of treatment / exposure:
- Initial test: observation at 3 minutes, 1 hour, 4 hours
Confirmatory test: 4 hours - Observation period:
- Erythema and edema scores are determined at 60 minutes, 24, 48, and 72 hours after patch removal. Further observations may be needed to establish reversibility.
- Number of animals:
- 3 Animals
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 60 minutes/24 hours/48 hours/72 hours
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- other: not applicable
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 60 minutes/24 hours/48 hours/72 hours
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- other: not applicable
- Irritant / corrosive response data:
- No irritation/corrosion
Any other information on results incl. tables
Body Weights: All of the animals exhibited weight gain during the study.
Clinical Observations: No overt signs of toxicity were evident in any of the animals during the course of the study.
Dermal Irritation: No signs of erythema or edema were observed in any of the three animals during the study.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The test substance was evaluated for its potential to produce skin irritation and/or corrosion after a single topical application for four hours to the intact skin of New Zealand White rabbits. No signs of erythema or edema were noted at any observation period. Based upon the evaluation criteria of the protocol, the test substance is considered a non-irritant.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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