Registration Dossier
Registration Dossier
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EC number: 402-400-4 | CAS number: 54660-00-3
Endpoint summary
Administrative data
Description of key information
Skin Irritation: not irritant; OECD 404, CIBA 1986c
Eye Irritation: not irritant; OECD 405, CIBA 1986d
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
There are valid in vivo data available for the assessment of the skin and eye irritation potential of Pyrrolo(3,4-c)pyrrole-1,4-dione, 2,5-dihydro-3,6-diphenyl-.
Skin: In a primary dermal irritation study (OECD 404, CIBA, 1986c), 3 female New Zealand White rabbits were dermally exposed to 0.5 mg of the test substance for 4 hours under occlusive conditions. Animals then were observed for 72 hours. Irritation was scored by the method of Draize as described in the OECD guideline 404. The mean score for the 24, 48 and 72 h reading for erythema and edema were 0. In this study, the test substance is not a dermal irritant.
Eye
An eye irritation test was performed with three New Zealand White rabbits according to OECD 405 (CIBA 1986d). Eyes were left unwashed after application of 0.1 g of the test substance and the animals were observed 72 h. The mean scores for the 24, 48 and 72 h reading for conjunctivae redness, iritis, cornea opacity and conjunctivae chemosis were 0 at any reading time point.
Respiratory system
No data available
Justification for classification or non-classification
Dangerous Substance Directive (67/548/EEC)
The available studies are considered reliable and suitable for classification purposes under 67/548/EEC. As a result the substance is not considered to be classified for skin and eye irritation under Directive 67/548/EEC, as amended for the 28th time in Directive 2001/59/EC.
Classification, Labelling, and Packaging Regulation (EC) No. 1272/2008
The available experimental test data are reliable and suitable for classification purposes under Regulation 1272/2008. As a result the substance is not considered to be classified for skin and eye irritation under Regulation (EC) No. 1272/2008.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
