Registration Dossier
Registration Dossier
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EC number: 402-400-4 | CAS number: 54660-00-3
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
Data on the long-term toxicity to Daphnia magna of an analogous substance (EC 401 -540 -3) are available (CIBA-GEIGY 1990b).
The overall NOEC for reproduction in a long term study on daphnids was found to exceed the range of water solubility.The read-across substance (EC 401-540-3) has similar physicochemical, toxicological and ecotoxicological properties. It is also of low water solubility and degradation and hydrolysis are not likely. Due to the inert structure no break-down products will occur in the environmental compartments.
The read-across substance differs by an additional chlorine in para-position of both phenyl rings. Therefore, the molecular diameter is slightly larger and the solubility in organic solvents expected to be slightly better. The common functional group is the 2,5 -dihydro-pyrrolo(3,4 -c)pyrrole-1,4 dione core. It is the chromophore that is both poorly soluble in organic and in inorganic solvents. The additional chlorines of the read-across substance may render it slightly better soluble in organic solvents. Additionally, it can be assumed based on the additional chlorines that the water solubility is predicted to be even lower and the logPow higher.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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