Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Key value for chemical safety assessment

Effects on fertility

Description of key information




Effects on developmental toxicity

Description of key information
The developmental toxicity of Triethylene glycol dimethyl ether was evaluated in two oral studies in rabbits and mice equivalent to OECD guideline 414.
Embryotoxicity such as reduced litter size and malformation was found in absence of clear maternal toxicity.
The NOAEL(developmental) in rabbits was 75 mg/kg/d and in mice was 250 mg/kg/d.
Additional information


Toxicity to reproduction: other studies

Additional information

Please refer to "Effects on fertility" and "Developmental toxicity"

Justification for classification or non-classification

Due to the observed effects on testes, epididymides and spermatogenesis of male test animals and the fetal toxicity of Triethylene glycol dimethyl ether a classification for reproductive toxicity is appropriate. It should be labelled as Reprotox Cat 1B; H360DF. 

Additional information