Registration Dossier

Administrative data

Link to relevant study record(s)

Description of key information

Based on physical properties, all members of this category are not expected to be internally absorbed and any absorbed amount is expected to be rapidly excreted due to the physical properties and the inability to be metabolized.

Key value for chemical safety assessment

Additional information

Based on physical properties, all members of this category are not expected to be internally absorbed and any absorbed amount is expected to be rapidly excreted due to the physical properties and the inability to be metabolized. Due to the stability of the carbon-fluorine bond, the members of this category are unable to be metabolized by aerobic organisms. Reactive oxygen species such as ∙OH or O(1D) are not sufficiently oxidizing to displace fluorine atoms from a carbon backbone. As such, normal phase I enzymes such as cytochrome P450s are unable to attack the carbon-fluorine bond. Heteroatoms such as nitrogen or oxygen, which may be present in some category members, are deactivated by the electron-withdrawing power of the perfluoroalkyl portions of the molecule and do not undergo the same reactions as would be expected in the corresponding non-fluorinated amines, ethers or morpholines. For example, the perfluorinated tertiary amine N cannot be protonated, alkylated, acylated or chemically oxidized under physiological conditions.

Please see IUCLID section 13 for the category justification and a matrix of toxicological and physicochemical data for members of the Perfluorinated Organic Chemicals C5-C18 category.