Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 206-841-1 | CAS number: 382-28-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1992
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study conducted under GLP conditions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1992
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Reinhardt, 1971, 1973 "Cardiac arrhythmias and aerosol sniffing" Arch. of Environ. Health, vol 22, pp 265-269; Epinephrine induced cardiac arrhythimia poetential of some common industrial solvents, Journal of Occupational Medicine, vol 15, pp 953-955
- Deviations:
- no
- Principles of method if other than guideline:
- The cardiac sensitisation potential of the test article was examined utilizing six beagle dogs. Adrenaline was administered intravenously before and during inhalation of the test substance. The effect of adrenaline on the ECG was compared. Positive evidence of cardiac sensitisation was taken as the presence of multiple multifocal ectopic beats following adrenaline administration during gas inhalation with little or no response to the same adrenaline dose in the absence of the test substance.
- GLP compliance:
- yes
Test material
- Reference substance name:
- T-5452
- IUPAC Name:
- T-5452
- Test material form:
- other: Liquid
- Details on test material:
- - Name of test material (as cited in study report: T-5452
- Substance type: Liquid
- Physical state: Liquid
- Analytical purity: >98%
- Lot/batch no.: 102
- Storage condition of test material: Stored at ambient (outdoor) temperature or at room temperature during the period of the study.
Constituent 1
Results and discussion
Any other information on results incl. tables
- Sex: male
- Endpoint: EC50
- Effect level: >23
- Unit of dose: %
- Remarks: No cardiac effcts noted at the highest exposure concentration
- Mortality: none
- Clinical signs: No data
- Body weight and weight gain: No data
- Gross pathology: NA
Applicant's summary and conclusion
- Conclusions:
- Cardiac sensitization EC50 > 23%.
- Executive summary:
This study was designed to assess the cardiac sensitization potential of the test article in beagle dogs. Adrenaline was administered by intravenous injection before and during inhalation of the test article. The effect of the adrenaline on the ECG pattern was examined. Positive evidence of cardiac sensitization would be observed as the presence of multiple multifocal ectopic beats or ventricular fibrillation following adrenaline administration during inhalation of the test substance. No such effect should be observed in the absence of the test article. The test article was administered at concentrations of 0 (control), 5, 10, 20, and 23% v/v in air. No signs of cardiac sensitization were observed in any dogs at any dose level. The results of the study show that the test article is without potential to cause cardiac sensitization in dogs at 23% v/v, the maximum attainable concentration in air.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

EU Privacy Disclaimer
This website uses cookies to ensure you get the best experience on our websites.