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EC number: 206-841-1 | CAS number: 382-28-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
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- Particle size distribution (Granulometry)
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- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
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- Nanomaterial pour density
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- Endpoint summary
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- Environmental data
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- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
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- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
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- Biological effects monitoring
- Biotransformation and kinetics
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- Toxicokinetics, metabolism and distribution
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- Irritation / corrosion
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- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Henry's Law constant
Administrative data
- Endpoint:
- Henry's law constant
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 07 Feb 2012 - 13 Feb 2012
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study well documented, accepted method
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Henry´s Law Constant was determined by measuring the FC-3284 concentrations in gas-phase and in aqueous-phase for a given test system vessel at equilibrium conditions and at ambient temperature and pressure.
Test material
- Reference substance name:
- FC-3284
- IUPAC Name:
- FC-3284
- Details on test material:
- - Name of test material (as cited in study report): FC-3284
- Substance type: single-constituent substance
- Physical state: Clear and colorless liquid
- Analytical purity: 96.67%
- Storage condition of test material: room temperature
Constituent 1
Results and discussion
Henry's Law constant H
- H:
- 7 060
- Temp.:
- 22 °C
- Atm. press.:
- 760 mm Hg
- Remarks on result:
- other: Test conducted at ambient temperature. Henry's Law constant result is reported as a dimensionless ratio of headspace over aqueous phase concentration. The average HLC was 7060 with %RSD of 4.8%. The average log HLC was 3.8, with %RSD of 0.54%.
Any other information on results incl. tables
Table 1: Summary of Henry’s Law Constant (HLC) for FC-3284
Ratio (Headspace: Aqueous) |
Replicate |
Day 1 |
Day 2 |
Day 3 |
70 % Headspace |
1 |
7620 |
7290 |
6610 |
2 |
7560 |
6930 |
6840 |
|
Average |
7590 |
7110 |
6730 |
|
%RPD |
0.79 |
5.1 |
3.4 |
|
50 % Headspace |
1 |
7350 |
6930 |
6820 |
2 |
7040 |
7300 |
6700 |
|
Average |
7200 |
7120 |
6760 |
|
%RPD |
4.3 |
5.2 |
1.8 |
|
30 % Headspace |
1 |
7520 |
7190(1) |
6730(1) |
2 |
7180 |
6490 |
6960 |
|
Average |
7350 |
6840 |
6850 |
|
%RPD |
4.6 |
10 |
3.4 |
|
Intra-Day Average % RSD |
7380 3.1 |
7020 4.4 |
6780 1.8 |
|
Overall Average %RSD |
7060 4.8 |
(1) One headspace measurement for Replicate 1 was determined to be a statistical outlier and was excluded from
the HLC determination
Table 2: Summary of Log (HLC) for FC-3284
Ratio (Headspace: Aqueous) |
Replicate |
Day 1 |
Day 2 |
Day 3 |
70 % Headspace |
1 |
3.9 |
3.9 |
3.8 |
2 |
3.9 |
3.8 |
3.8 |
|
Average |
3.9 |
3.9 |
3.8 |
|
%RPD |
0.09 |
0.57 |
0.39 |
|
50 % Headspace |
1 |
3.9 |
3.8 |
3.8 |
2 |
3.8 |
3.9 |
3.8 |
|
Average |
3.9 |
3.9 |
3.8 |
|
%RPD |
0.49 |
0.59 |
0.2 |
|
30 % Headspace |
1 |
3.9 |
3.9 |
3.8 |
2 |
3.9 |
3.8 |
3.8 |
|
Average |
3.9 |
3.8 |
3.8 |
|
%RPD |
0.52 |
1.2 |
0.38 |
|
Intra-Day Average % RSD |
3.9 0.35 |
3.8 0.51 |
3.8 0.21 |
|
Overall Average %RSD |
3.8 0.54 |
Table 3: Individual results of Henry’s Law Constant (HLC) for FC-3284 |
|||||
Day 1, 70% Headspace |
|||||
|
Water conc (ng/mL) |
Headspace conc. (ng/mL) |
HLC |
log HLC |
|
Replicate 1 |
aliquot 1 |
0.870 |
6870 |
||
aliquot 2 |
0.919 |
6770 |
|||
Average |
0.895 |
6820 |
7620 |
3.9 |
|
% RPD |
5.4 |
1.5 |
|||
Replicate 2 |
aliquot 1 |
0.927 |
6800 |
||
aliquot 2 |
0.878 |
6860 |
|||
Average |
0.903 |
6830 |
7560 |
3.9 |
|
% RPD |
5.4 |
0.8 |
|||
Day 1, 50% Headspace |
|||||
|
Water conc. (ng/mL) |
Headspace conc (ng/mL) |
HLC |
log HLC |
|
Replicate 1 |
aliquot 1 |
0.953 |
6710 |
||
aliquot 2 |
0.897 |
6890 |
|||
Average |
0.925 |
6800 |
7350 |
3.9 |
|
% RPD |
6.0 |
2.7 |
|||
Replicate 2 |
aliquot 1 |
1.01 |
6840 |
||
aliquot 2 |
0.934 |
6880 |
|||
Average |
0.974 |
6860 |
7040 |
3.8 |
|
% RPD |
8.2 |
0.6 |
|||
Day 1, 30% Headspace |
|||||
|
Water conc. (ng/mL) |
Headspace conc. (ng/mL) |
HLC |
log HLC |
|
Replicate 1 |
aliquot 1 |
0.945 |
6700 |
||
aliquot 2 |
0.875 |
6970 |
|||
Average |
0.910 |
6840 |
7520 |
3.9 |
|
% RPD |
7.7 |
4.0 |
|||
Replicate 2 |
aliquot 1 |
0.975 |
6700 |
||
aliquot 2 |
0.895 |
6710 |
|||
Average |
0.935 |
6710 |
7180 |
3.8 |
|
% RPD |
8.6 |
0.26 |
|||
Day 2, 70% Headspace |
|||||
|
Water conc (ng/mL) |
Headspace conc. (ng/mL) |
HLC |
log HLC |
|
Replicate 1 |
aliquot 1 |
0.991 |
7000 |
|
|
aliquot 2 |
0.914 |
6890 |
|
||
Average |
0.953 |
6950 |
7290 |
3.9 |
|
% RPD |
8.0 |
1.7 |
|
||
Replicate 2 |
aliquot 1 |
1.05 |
6890 |
|
|
aliquot 2 |
0.939 |
6910 |
|
||
Average |
0.996 |
6900 |
6930 |
3.8 |
|
% RPD |
12 |
0.20 |
|
|
|
Day 2, 50% Headspace |
|||||
|
Water conc. (ng/mL) |
Headspace conc (ng/mL) |
HLC |
log HLC |
|
Replicate 1 |
aliquot 1 |
0.990 |
6780 |
|
|
aliquot 2 |
0.964 |
6760 |
|
||
Average |
0.977 |
6770 |
6930 |
3.8 |
|
% RPD |
2.7 |
0.34 |
|
||
Replicate 2 |
aliquot 1 |
0.956 |
6760 |
|
|
aliquot 2 |
0.894 |
6730 |
|
||
Average |
0.925 |
6750 |
7300 |
3.9 |
|
% RPD |
6.7 |
0.57 |
|
||
Day 2, 30% Headspace |
|||||
|
Water conc. (ng/mL) |
Headspace conc. (ng/mL) |
HLC |
log HLC |
|
Replicate 1 |
aliquot 1 |
0.980 |
6780 |
|
|
aliquot 2 |
0.906 |
1300 (1) |
|
||
Average |
0.943 |
6780 (1) |
7190 |
3.9 |
|
% RPD |
7.8 |
NA (2) |
|
||
Replicate 2 |
aliquot 1 |
1.09 |
6800 |
|
|
aliquot 2 |
0.994 |
6700 |
|
||
Average |
1.04 |
6750 |
6490 |
3.8 |
|
% RPD |
9.1 |
1.5 |
|
||
Day 3, 70% Headspace |
|||||
|
Water conc (ng/mL) |
Headspace conc. (ng/mL) |
HLC |
log HLC |
|
Replicate 1 |
aliquot 1 |
1.08 |
6560 |
|
|
aliquot 2 |
0.999 |
7170 |
|
||
Average |
1.04 |
6870 |
6610 |
3.8 |
|
% RPD |
8.2 |
9.0 |
|
||
Replicate 2 |
aliquot 1 |
1.06 |
7220 |
|
|
aliquot 2 |
1.05 |
7280 |
|
||
Average |
1.06 |
7250 |
6840 |
3.8 |
|
% RPD |
1.2 |
0.73 |
|
||
Day 3, 50% Headspace |
|||||
|
Water conc. (ng/mL) |
Headspace conc (ng/mL) |
HLC |
log HLC |
|
Replicate 1 |
aliquot 1 |
1.10 |
7170 |
||
aliquot 2 |
0.995 |
7410 |
|||
Average |
1.05 |
7160 |
6820 |
3.8 |
|
% RPD |
10 |
0.40 |
|||
Replicate 2 |
aliquot 1 |
1.14 |
7050 |
||
aliquot 2 |
0.96 |
7000 |
|||
Average |
1.05 |
7030 |
6700 |
3.7 |
|
% RPD |
17 |
0.71 |
|||
Day 3, 30% Headspace |
|||||
|
Water conc. (ng/mL) |
Headspace conc. (ng/mL) |
HLC |
log HLC |
|
Replicate 1 |
aliquot 1 |
1.15 |
3820 (1) |
|
|
aliquot 2 |
1.00 |
7270 |
|
||
Average |
1.080 |
7270 (1) |
6730 |
3.8 |
|
% RPD |
14 |
NA (2) |
|
||
Replicate 2 |
aliquot 1 |
1.05 |
7310 |
|
|
aliquot 2 |
1.00 |
7040 |
|
||
Average |
1.03 |
7170 |
6960 |
3.8 |
|
% RPD |
5.3 |
3.8 |
|
||
(1) Result determined to be a statistical outlier at the 98% confidence level. |
|||||
(2) N=1. %RPD was not calculated. |
Applicant's summary and conclusion
- Conclusions:
- The Henry's Law constant (HLC) for FC-3284 was determined to be 7060 at 22 °C based on measured concentrations in the headspace phase and water phase. The average log HLC was 3.8.
- Executive summary:
The Henry's Law constant of FC-3284 was determined by the ratio of headspace concentration over aqueous phase concentration.
Duplicate test vessels were filled with water and dosed with FC-3284 gas at three headspace: water ratios. The vials were incubated for 1, 2 and 3 days at ambient temperature. Both the headspace and the water phase for each vials were sampled and analyzed in duplicates using purge and trap gas chromatography/mass spectrometry (GC/MS).
The average Henry's Law constant for FC-3284 was 7060 at 22 °C. The Henry's Law constant expressed as log HLC is 3.8 at 22 °C.
This study was conducted under GLP compliance with accepted calculation method. Therefore, it is considered reliable without restrictions.
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