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Categories

Category name:
inerts category

Justifications and discussions

Category definition:
The Perfluorinated Organic Chemicals, C5-C18, category is defined as a chemically related group of substances containing only carbon, fluorine and at most one oxygen and/or nitrogen atom. All of these chemicals stem from the same manufacturing process, have similar physicochemical properties including high vapor pressure and low water solubility relative to the hydrocarbon analogs (e.g., hexanes v. perfluorohexanes), and also lack any chemically reactive groups, which forms the technical basis for the category. Members of this category are fully fluorinated, meaning that fluorine, rather than hydrogen, is bonded to all carbon atoms in the molecule. Fluorine is the most electronegative of the elements (fluorine has an electronegativity of 3.98 on the Pauling scale, as compared to 2.55 for carbon or 2.20 for hydrogen). This electronegativity is expected to dominate over all other aspects of substance chemistry and is the underlying basis for similarity of substances in this category.
Category rationale:
The Perfluorinated Organic Chemicals, C5-C18, category includes, but is not limited to, the following substances:

Perfluorohexanes, CAS# 1064697-81-9
Perfluorohepanes, CAS# 1064698-16-3
Perfluorotributylamines, CAS# 1064698-37-8
Perfluorotripropylamines, CAS# 338-83-0
Perfluoro-N-methylmorpholine, CAS# 382-28-5
Perfluoro-N-C1,3-alkyl morpholines, CAS# 1093615-61-2
Perfluoro-C6,8-furans, pyrans and acyclic ethers , CAS# 1064698-52-7

Data on physicochemical properties, environmental fate and pathways, mammalian toxicity, and ecotoxicity have been collected for these category members. Because these substances exhibit similarity in their physicochemical properties and toxicological properties in mammals, and because available data indicates that parent molecules are not reactive toward biological molecules and cannot undergo bioactivation by normal enzymatic processes, they can be considered to constitute a chemical category. Data gaps for partitioning properties, mammalian and ecological toxicity can therefore be addressed by read-across and/or trend analysis between category members.

The members of this category have formerly been described in the EU under the generic CAS# 86508-42-1, and are listed in chemical inventories of other jurisdictions under this generic number.