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Toxicological information

Specific investigations: other studies

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Administrative data

Endpoint:
endocrine system modulation
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
13.11.2012 - 23.11.2012
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: recent study conducted according to reliable in-house protocol

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2013
Report Date:
2013

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: according to E. Routledge and J.P. Sumpter (1996)
Principles of method if other than guideline:
The aim of the study was to determine the estrogenic and antiestrogenic potential of (4nonylphenoxy) acetic acid. The yeast cells used in the yeast estrogen screening (YES) assay have been stably transformed with genes for the human estrogen receptor a and the ß-galactosidase reporter gene. Estrogenic as weil as antiestrogenic potentials of the test substances mediated by receptor binding or blocking can be determined using this assay, respectively.
GLP compliance:
no
Type of method:
in vitro

Test material

Reference
Name:
Unnamed
Type:
Constituent

Administration / exposure

Vehicle:
DMSO

Results and discussion

Details on results:
ln this study, the test substance showed no estrogenic activity in comparison to 17ß-estradiol. ln this study, the test substance showed no antiestrogenic activity in comparison to hydroxytamoxifen.

Applicant's summary and conclusion