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Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Report date:
2015

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 425 (Acute Oral Toxicity: Up-and-Down Procedure)
GLP compliance:
yes (incl. QA statement)
Test type:
up-and-down procedure
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
3-(3,4,5-trimethoxybenzylidene)pentane-2,4-dione
EC Number:
807-059-9
Cas Number:
945558-97-4
Molecular formula:
C15H18O5
IUPAC Name:
3-(3,4,5-trimethoxybenzylidene)pentane-2,4-dione

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water
Doses:
2000 mg/kg
No. of animals per sex per dose:
5
Control animals:
no

Results and discussion

Effect levels
Sex:
female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Mortality:
0
Clinical signs:
one animal exhibited irregular respiration, ataxia and reduced fecal volume. However, the animal recovered on Day 2 and along with the remaining animals appeared active and healthy for the remainder of the study.
Body weight:
Initial D-7 D-14
160 181 204
160 186 202
164 199 218
169 200 218
169 196 215
Gross pathology:
No gross abnormalities

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
the acute oral LD50 of 3-(3,4,5-Trimethoxy benzylidene)-2,4-pentanedione is greater than 2,000 milligrams per kilogram of body weight in female rats.