Registration Dossier
Registration Dossier
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EC number: 807-059-9 | CAS number: 945558-97-4
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Report date:
- 2015
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 425 (Acute Oral Toxicity: Up-and-Down Procedure)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- up-and-down procedure
- Limit test:
- yes
Test material
- Reference substance name:
- 3-[(3,4,5-trimethoxyphenyl)methylidene]pentane-2,4-dione
- EC Number:
- 807-059-9
- Cas Number:
- 945558-97-4
- Molecular formula:
- C15H18O5
- IUPAC Name:
- 3-[(3,4,5-trimethoxyphenyl)methylidene]pentane-2,4-dione
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- 0
- Clinical signs:
- other: one animal exhibited irregular respiration, ataxia and reduced fecal volume. However, the animal recovered on Day 2 and along with the remaining animals appeared active and healthy for the remainder of the study.
- Gross pathology:
- No gross abnormalities
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- the acute oral LD50 of 3-(3,4,5-Trimethoxy benzylidene)-2,4-pentanedione is greater than 2,000 milligrams per kilogram of body weight in female rats.
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