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Diss Factsheets
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EC number: 208-015-6 | CAS number: 505-65-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 968
- Report date:
- 1968
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- GLP compliance:
- no
- Remarks:
- ; GLP was not compulsory at the time the study was conducted
- Limit test:
- no
Test material
- Reference substance name:
- 1,3-dioxepane
- EC Number:
- 208-015-6
- EC Name:
- 1,3-dioxepane
- Cas Number:
- 505-65-7
- Molecular formula:
- C5H10O2
- IUPAC Name:
- 1,3-dioxepane
- Details on test material:
- Butandiolformal (1,3-Dioxacycloheptane)
Purity 99.99%
Physical state: liquid
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- NMRI
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Designation: Kisslegg mice
Source: no data
Age at test initiation: no data
Bodyweight range at test initiation: male 30-47g, female 26-40g
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- other: Traganth
- Details on exposure:
- The test substance was offered to the animals as aqueous emulsion using Traganth as vehicle at following concentrations: 2% , 4%, 8%, 10% and 20%.
The 20% test solution served for preparation of the 1.6 and 3.2 ml/kg bw dose levels, the application volume was 10 ml/kg bw;
The 10% test solution served for preparation of the 1.25 ml/kg bw dose level, the application volume was 12.5 ml/kg bw;
The 8% test solution served for the preparation of the 0.8 ml/kg bw dose level, the application volume was 10 ml/kg bw;
The 4% test solution served for the preparation of the 0.4 ml/kg bw dose level, the application volume was 10 ml/kg bw;
The 2% test solution served for the preparation of the 0.2 ml/kg bw dose level, the application volume was 10 ml/kg bw. - Doses:
- 200, 400, 800, 1250, 1600 and 2000 mg/kg bw
- No. of animals per sex per dose:
- 2000, 1600, 400 and 200 mg/kg bw: 5 animals/sex/dose were used;
1250 and 800 mg/kg bw: 10 animals/sex/dose were used; - Control animals:
- no
- Details on study design:
- A single dose of the test substance was injected in to the peritoneal cavity of the animals. The animals from the 200 to 1250 mg/kg bw dose groups were observed for a period of 7 days while the animals administered the doses 1600 and 2000 mg/kg bw were under observation for 14 days. Animals that died during the observation period were necropsied. At the end of the observation period, surviving animals were sacrificed and subjected to necropsy.
- Statistics:
- No data
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 500 mg/kg bw
- Remarks on result:
- other: (after14 days)
- Mortality:
- 2000 mg/kg bw: mortality was 10/10 animals after 7 days, first cases of death occurred within 24 hours following injection;
1600 mg/kg bw: mortality was 7/10 animals after 7 days and reached 9/10 after 14, first cases of death occurred within 24 hours following injection;
1250 mg/kg bw: mortality was 0/20;
800 mg/kg bw: 2/20 animals died between 2 and 7 days following injection;
400 mg/kg bw: mortality was 0/10;
200 mg/kg bw: mortality was 0/10. - Clinical signs:
- 2000 and 1600 mg/kg bw:
Symptoms observed immediately after application included staggering, jumping convulsions, pain noise, streaking gait (hind limbs). After 2 minutes, side and prone position, dyspnea, partly apathy and partly narcotic state were observed. On the following days, prone position, labored respiration, scrubby fur and clotted eyes were observed. Except for one mice of the 1600 mg/kg bw group, all animals died; the surviving mice recovered slowly, and complete recovery was seen on day 12 post-exposure.
1250 to 200 mg/kg bw:
In these groups, symptoms observed immediately after application included staggering, jumping convulsions, pain noise and labored respiration. On the following days, accelerated respiration and scrubby fur were observed. The surviving animals recovered within 2 to 4 days following injection. - Body weight:
- No data on terminal body weights were available.
- Gross pathology:
- Nearly all animals that died showed more or less firm intraabdominal adhesions; in three cases, sections of the small intestine partly showed vascular injection; in one case, the gastrointestinal tract showed bloody contents.
All animals that were sacrificed at the end of the observation period showed slight to firm adhesions (between liver and stomach, intraabdominal or in the liver).
Applicant's summary and conclusion
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