Registration Dossier
Registration Dossier
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EC number: 410-260-0 | CAS number: 83857-96-9 2-BUTYL-4-CHLORO-5-FORMYLIMIDAZOLE; BCFI
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- short-term repeated dose toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
- Year:
- 1 993
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Directive 84/449/CEE -B7
- GLP compliance:
- yes
- Limit test:
- no
Test material
- Reference substance name:
- 2-butyl-4-chloro-5-formylimidazole
- EC Number:
- 410-260-0
- EC Name:
- 2-butyl-4-chloro-5-formylimidazole
- Cas Number:
- 83857-96-9
- Molecular formula:
- C8 H11 Cl N2 O
- IUPAC Name:
- 2-butyl-4-chloro-1H-imidazole-5-carbaldehyde
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: solution aqueuse de méthylcellulose à 0,5%
- Duration of treatment / exposure:
- Test duration: 28 days
- Frequency of treatment:
- Dosing regime: 7 days/week
- No. of animals per sex per dose:
- Male: 6 animals at 0 mg/kg bw/day
Male: 6 animalsat 50 mg/kg bW/day
Male: 6 animals at 175 mg/kg bw/day
Male: 6 animals at 600 mg/kg bw/day
Female: 6 animals at 0 mg/kg bw/day
Female : 6 anima ls at 50 mg/kg bw/day
Female: 6 animals at 175 mglkg bw/day
Female: 6 animals at 600 mg/kg bw/day
Results and discussion
Effect levels
open allclose all
- Dose descriptor:
- NOAEL
- Effect level:
- 50 mg/kg bw/day (nominal)
- Basis for effect level:
- other: original NCO unit is mg/kg/day.
- Dose descriptor:
- NOEL
- Effect level:
- 50 mg/kg bw/day (nominal)
- Basis for effect level:
- other: original NCO unit is mg/kg/day.
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
Comments :
Les signes observés dans 1es groupes 3 et 4 traduisent une
toxicité hépatique. A 175 mg/ kg/ j , cel1e-ci reste discrète ,
avec des modifications histologiques de type réversibl e (pasde nécrose).
Ceci ne nécessite pas l'étiquetage Xn R48/22 .
Applicant's summary and conclusion
- Conclusions:
- Classified as: Not classified
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