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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
October - December 1990
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: meets generally accepted scientific principles, acceptable for assessment
Justification for type of information:
Data is from experimental study

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
1990
Report date:
1990

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
The skin irritation study of test chemical was conducted on single New Zealand White rabbits to assess its skin irritation potential.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
6-amino-4-hydroxynaphthalene-2-sulphonic acid
EC Number:
202-000-8
EC Name:
6-amino-4-hydroxynaphthalene-2-sulphonic acid
Cas Number:
90-51-7
Molecular formula:
C10H9NO4S
IUPAC Name:
6-amino-4-hydroxynaphthalene-2-sulfonic acid
Test material form:
solid
Details on test material:
- Name of test material (as cited in study report): 6-amino-4-hydroxynaphthalene-2-sulphonic acid
- Molecular formula : C10H9NO4S
- Molecular weight : 239.26g/mol
- Substance type: Organic
- Physical state: solid
- Purity: No data
- Impurities (identity and concentrations):No data

Test animals

Species:
rabbit
Strain:
New Zealand White
Details on test animals or test system and environmental conditions:
not specified

Test system

Type of coverage:
not specified
Preparation of test site:
other: scarified skin
Vehicle:
water
Controls:
not required
Amount / concentration applied:
500 mg
Duration of treatment / exposure:
4 hours
Observation period:
24, 48, 72 hours
Number of animals:
1
Details on study design:
- Parameters analysed / observed: hyperemia, edema on intact or scarified skin

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
other: observation of intact skin
Basis:
animal #1
Time point:
24 h
Score:
0
Remarks on result:
no indication of irritation
Irritation parameter:
other: observation of scarified skin
Basis:
animal #1
Time point:
24 h
Score:
> 1 - < 2
Remarks on result:
other: slight congestion, slight edema
Irritation parameter:
other: observation of scarified skin
Basis:
animal #1
Time point:
other: 48/72 h
Score:
> 1 - < 2
Remarks on result:
other: very weak edema

Applicant's summary and conclusion

Interpretation of results:
other: Not irritating
Conclusions:
The test chemical was considered to be not irritating to the intact or scarified skin New Zealand White rabbits after exposure of 4 hours.
Executive summary:

The acute dermal irritation study of test chemical was conducted on New Zealand White rabbit to assess its skin irritation potential.

500mg of chemical was applied for 4 hours and skin was analyzed hyperemia, edema on intact or scarified skin at 24, 48, 72 hours after exposure.

Since the test chemical did not induce any skin reaction, it was considered as not irritating to the intact or scarified skin New Zealand White rabbits after exposure of 4 hours.