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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from publication.

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Toxicity of test material
Author:
Greim et al.
Year:
1994
Bibliographic source:
Chemosphere
Reference Type:
other: Authoritative database
Title:
Toxicity of test chemical
Author:
IFA GESTIS
Year:
2018
Bibliographic source:
GESTIS Substance Database
Reference Type:
other: Secondary source
Title:
Acute oral toxicity of test chemical
Author:
BG Chemie
Year:
2000
Bibliographic source:
BG Chemie

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: As mentioned below
Principles of method if other than guideline:
Acute oral toxicity of the given test chemical in rat.
GLP compliance:
not specified
Test type:
other: not specified
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
6-amino-4-hydroxynaphthalene-2-sulphonic acid
EC Number:
202-000-8
EC Name:
6-amino-4-hydroxynaphthalene-2-sulphonic acid
Cas Number:
90-51-7
Molecular formula:
C10H9NO4S
IUPAC Name:
6-amino-4-hydroxynaphthalene-2-sulphonic acid
Details on test material:
- IUPAC Name: 6-amino-4-hydroxynaphthalene-2-sulphonic acid
- Common Name: Gamma acid
- InChI: 1S/C10H9NO4S/c11-7-2-1-6-3-8(16(13,14)15)5-10(12)9(6)4-7/h1-5,12H,11H2,(H,13,14,15)
- Smiles: c12c(c(cc(c1)S(O)(=O)=O)O)cc(N)cc2
- Molecular formula :C10H9NO4S
- Molecular weight :239.25 g/mol
- Substance type:Organic
- Physical state:Solid, powder dark brown

Test animals

Species:
rat
Strain:
Wistar
Sex:
male
Details on test animals or test system and environmental conditions:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
water
Details on oral exposure:
not specified
Doses:
5000 mg/kg bw
No. of animals per sex per dose:
Total = 10
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Animals were observed for mortality and clinical signs.
Statistics:
not specified

Results and discussion

Preliminary study:
not specified
Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
Mortality:
No mortality was observed at 5000 mg/kg bw in treated animals.
Clinical signs:
Clinical symptoms were not observed in treated animals.
Body weight:
not specified
Gross pathology:
not specified
Other findings:
not specified

Applicant's summary and conclusion

Interpretation of results:
other: Not classified
Conclusions:
The acute oral LD50 value was considered to be >5000 mg/kg bw, when 10 male Wistar rats were treated with the given test chemical via oral route.
Executive summary:

Acute oral toxicity study was conducted by using the given test chemical in 10 male Wistar rats at the dose concentration of 5000 mg/kg bw.

The given test chemical was dissolved or suspended in water and administered via oral route.

Animals were observed for mortality and clinical signs for 14 days. No mortality was observed at 5000 mg/kg bw in treated animals. Clinical symptoms were not observed in treated animals.

Hence, the LD50 value was considered to be >5000 mg/kg bw, when 10 male Wistar rats were treated with the given test chemical via oral route.